mAChR Control

rel-VU6021625 is the relative configuration of VU6021625 (HY-160440A). VU6021625 is a potent and selective mAChR M4 antagonist with IC₅₀ values of 0.44 nM and 57 nM for human M4, rat M4, respectively.

(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC₅₀>10 μM).

6-Hydroxytropinone (Standard) is the analytical standard of 6-Hydroxytropinone. This product is intended for research and analytical applications. 6-Hydroxytropinone is a cyclic hydroxylation product of Tropinone (HY-Y0135), and serves as an indicator for tropane alkaloid metabolism in plants or microorganisms. 6-Hydroxytropinone itself has no significant anticholinergic toxicity, nor does it act as a substrate for Tropine (HY-N7061) dehydrogenase.

(±)-Darifenacin N-Oxide is the impurity of Darifenacin (HY-A0033). Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pK_i of 8.9.

Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.

6-Hydroxytropinone is a cyclic hydroxylation product of Tropinone (HY-Y0135), and serves as an indicator for tropane alkaloid metabolism in plants or microorganisms. 6-Hydroxytropinone itself has no significant anticholinergic toxicity, nor does it act as a substrate for Tropine (HY-N7061) dehydrogenase.

(Rac)-5-Carboxy tolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist Tolterodine (HY-A0024).

(R)-VU 6008667 (Standard) is the analytical standard of (R)-VU 6008667 (HY-101281B). This product is intended for research and analytical applications. (R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC50>10 μM).

Solifenacin N-oxide (Solifenacin N1-oxide) is an inactive metabolite of the muscarinic receptor antagonist Solifenacin (HY-A0034).