Ser/Thr Kinase
Protein Serine-Threonine Kinase
Ser/Thr Kinase belongs to the eukaryotic protein kinase (ePK) superfamily and can use ATP to phosphorylate the hydroxyl group of serine or threonine residues in the kinase recognition amino acid sequence. The widely known anticancer targets in the Ser/Thr Kinase family are protein kinase C (PKC) and cyclin-dependent kinases (CDKs). There are two types of Ser/Thr Kinase: one is a kinase that phosphorylates receptor molecules, i.e., receptor protein serine/threonine kinases, such as activated receptor kinases and transforming growth factor β receptor kinases; the other is a kinase that acts as an intracellular signal transduction protein. The latter can phosphorylate several key targets of multiple signaling pathways and affect a variety of biological functions including growth, differentiation, cell cycle progression, and metabolism. This family contains several different groups of kinases, including (1) the CK group of kinases: casein kinases; (2) the AGC group: the kinases protein kinase A (PKA), protein kinase B (PKB or v-akt murine thymoma viral oncogene homolog 1: AKT1), and protein kinase C (PKC); (3) the CAMK group of kinases: Ca2+/calmodulin-dependent kinases; (4) the CMGC group of kinases: mos/raf kinases, mitogen-activated kinases (MAPKs), cyclin-dependent kinases (CDKs), and glycogen synthase kinases (GSKs); and (5) the STE group of kinases: homologs of yeast sterile kinases 7, 11, and 20 kinases.Ser/Thr Kinase family regulates the glucocorticoid receptor (GR), a nuclear hormone receptor superfamily protein. For example, MAPK, CDK, PKB/AKT1 and GSK3β can phosphorylate GR at specific residues; PKA, AKT1, PKC, MAPK, AMPK and mTOR can additionally phosphorylate other kinases and/or transcriptional cofactors associated with DNA-associated GR to indirectly regulate GR. It is worth mentioning that p38 MAPK in the MAPK family regulates serine phosphorylation of GR through upstream MAP2K2/4, while another JNK inhibits GR transcriptional activity by enhancing the nuclear export of the receptor[1][2].
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Ser/Thr Kinase Related Products (52)
Related Products (52)
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STK16-IN-1 (Standard)
0 ImagesCat. No.: HY-101270RCAS No.: 1223001-53-3STK16-IN-1 (Standard) is the analytical standard of STK16-IN-1 (HY-101270). This product is intended for research and analytical applications. STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
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Protein kinase inhibitor 14
0 ImagesCat. No.: HY-171291CAS No.: 928319-09-9Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects against a variety of serine/threonine kinase and receptor/non-receptor tyrosine kinase.
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Protein kinase G inhibitor-3
0 ImagesCat. No.: HY-169587CAS No.: 331964-66-0Protein kinase G inhibitor-3 (Compound 177) is an inhibitor of mycobacterial serine/threonine protein kinases. Protein kinase G inhibitor-3 can be used in the research of diseases related to mycobacterial infections.
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TAS0728 (Standard)
0 ImagesCat. No.: HY-111553RCAS No.: 2088323-16-2TAS0728 (Standard) is the analytical standard of TAS0728 (HY-111553). This product is intended for research and analytical applications. TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMX、HER4、BLK、EGFR、JAK3、SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors.
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Protein kinase inhibitor 15
0 ImagesCat. No.: HY-171293CAS No.: 928317-20-8Protein kinase inhibitor 15 (Compound A.35.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
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BAY-1816032 (Standard)
0 ImagesCat. No.: HY-103020RCAS No.: 1891087-61-8BAY-1816032 (Standard) is the analytical standard of BAY-1816032 (HY-103020). This product is intended for research and analytical applications. BAY-1816032, a chemical probe, is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM.
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Inh2-B1
0 ImagesCat. No.: HY-122735CAS No.: 690216-38-7Inh2-B1 is a Ser/Thr protein kinase (STK1) inhibitor. Inh2-B1 specifically inhibits STK1 activity by directly binding to its ATP-binding catalytic domain. Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) clearly.
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BAY-524 (Standard)
0 ImagesCat. No.: HY-104001RCAS No.: 1445830-39-6BAY-524 (Standard) is the analytical standard of BAY-524 (HY-104001). This product is intended for research and analytical applications. BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents.
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TRULI (Standard)
0 ImagesCat. No.: HY-138489RCAS No.: 1424635-83-5Synonyms: Lats-IN-1 (Standard)
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Vibilsertib (hydrocholide)
0 ImagesCat. No.: HY-160169ASynonyms: Necrosis inhibitor 2 (hydrocholide)Vibilsertib (Necrosis inhibitor 2) hydrocholide (Compound B19), a serine/threonine kinase inhibitor, is a cell necrosis inhibitor. Vibilsertib hydrocholide can be used to study diseases related to the necrosis pathway, including inflammation, tumors, metabolic diseases and neurodegenerative diseases.
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SB-633825 (Standard)
0 ImagesCat. No.: HY-108333RCAS No.: 956613-01-7SB-633825 (Standard) is the analytical standard of SB-633825 (HY-108333). This product is intended for research and analytical applications. SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.
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PknB-IN-3
0 ImagesCat. No.: HY-183726PknB-IN-3 is a Mycobacterium tuberculosis Protein kinase B (PknB) inhibitor with an IC50 of 0.06 μM. PknB-IN-3 inhibits growth of Mycobacterium tuberculosis and can be used for the research of tuberculosis.
