SOS1 Inhibitor

DCAI hydrochloride is a KRas inhibitor with a K_d value of 1.1 mM. DCAI hydrochloride directly binds to the Ras protein and competitively inhibits SOS-mediated nucleotide release (IC₅₀ = 155 μM) and exchange reaction (IC₅₀ = 342 μM). DCAI hydrochloride binds to the pocket at the Ras-SOS interface and blocks the formation of the Ras-SOS complex intermediate by impeding salt bridge formation through steric hindrance and the induction of Ras conformational changes. DCAI hydrochloride is used in the study of wild-type and mutant Ras tumors.

2C07 is a mutant Ras (K-Ras^M72C, H-Ras^M72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research.

NSC-70220 (Standard) is the analytical standard of NSC-70220 (HY-101796). This product is intended for research and analytical applications. NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect.

Sos1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sos1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654).

VHL Ligand intermediate-1 (intermediate 18a) is an intermediate in the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs.