SWI/SNF Complex Inhibitor
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SMARCA2-IN-10
0 ImagesCat. No.: HY-W494890CAS No.: 82131-85-9SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM). SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma.
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NVS-BPTF-1
0 ImagesNVS-BPTF-1, a chemical probe, is a selective inhibitor for bromodomain and PHD finger containing transcription factor (BPTF), with KD of 71 nM.
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BRM/BRG1 ATP Inhibitor-3
0 ImagesCat. No.: HY-148373CAS No.: 2368901-31-7BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders.
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BRM/BRG1 ATP Inhibitor-4
0 ImagesCat. No.: HY-148374CAS No.: 2422030-94-0BRM/BRG1 ATP Inhibitor-4 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-4 can be used for the research of cancers and BAF complex-related disorders.
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(S)-GSK1379725A
0 ImagesCat. No.: HY-145431CAS No.: 2359618-49-6(S)-GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity.
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BI-7190
0 ImagesCat. No.: HY-160286CAS No.: 2001082-11-5BI-7190 is a selective BPTF inhibitor (Kd = 3.5 nM). BI-7190 can be used in the research of cancer.
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DC-BPi-07
0 ImagesCat. No.: HY-178697CAS No.: 2758411-53-7DC-BPi-07 is a selective BPTF inhibitor with an IC50 value of 16.0 nM against BPTF-H4. DC-BPi-07 can be used in the research of leukemia.
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DC-BPi-11
0 ImagesCat. No.: HY-141703CAS No.: 2758411-61-7DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
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SMARCA2-IN-8
0 ImagesCat. No.: HY-161887CAS No.: 2270875-93-7SMARCA2-IN-8 (Compound 13) is an orally active inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 (also known as Brahma homologue, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1) with IC50 of 5 and 6 nM. SMARCA2-IN-8 inhibits the proliferation of SMARCA2 mutated cancer cell SKMEL5 with AAC50 of 5 nM. SMARCA2-IN-8 downregulates the SMARCA2-dependent KRT80 gene expression with AAC50 of 10 nM. SMARCA2-IN-8 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice.
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IV-275
0 ImagesCat. No.: HY-155889IV-275 is an inhibitor of both BRG1 and BRM bromodomains. IV-275 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-275 inhibits the invasiveness of GBM cells. IV-275 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide.
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PBRM1-BD2-IN-7
0 ImagesCat. No.: HY-151534CAS No.: 2819989-68-7PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC50 value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer.
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BRM/BRG1 ATP-IN-7
0 ImagesCat. No.: HY-178488CAS No.: 2468048-19-1BRM/BRG1 ATP-IN-7 (Compound Cpd69) is a selective dual BRM (SMARCA2) and BRG1 (SMARCA4) inhibitor with IC50 values of 12 nM and 8 nM, respectively. BRM/BRG1 ATP-IN-7 is promising for research of BRM/BRG1-dependent cancers (e.g., non-small cell lung cancer, Ewing sarcoma) and virus-associated diseases (e.g., HPV infection).
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PBRM1-BD2-IN-3
0 ImagesCat. No.: HY-151530CAS No.: 2819989-58-5PBRM1-BD2-IN-3 (compound 12) is a potent PBRM1-BD2 inhibitor with an IC50 value of 1.1 μM. PBRM1-BD2 Inhibitor can be used to research anticancer.
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PBRM1-BD2-IN-6
0 ImagesCat. No.: HY-151533CAS No.: 2819989-67-6PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC50 value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer.
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PBRM1-BD2-IN-1
0 ImagesCat. No.: HY-151528CAS No.: 1915012-21-3PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer.
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BRM/BRG1 ATP-IN-5
0 ImagesCat. No.: HY-178481CAS No.: 2468046-57-1BRM/BRG1 ATP-IN-5 (Compound 6) is a BRG1/BRM inhibitor. BRM/BRG1 ATP-IN-5 acts on the BAF complex, which is involved in chromatin regulation and gene expression via ATP-dependent chromatin remodeling. BRM/BRG1 ATP-IN-5 demonstrates anti-tumor potential, particularly in cancers associated with BAF complex disorders.
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DCSM06
0 ImagesCat. No.: HY-161888CAS No.: 924855-67-4DCSM06 is an inhibitor for the bromodomain of SWI/SNF chromatin remodeling complexe SMARCA2 with an IC50 of 9.7 μM
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SMARCA2-IN-2
0 ImagesCat. No.: HY-162740CAS No.: 2568055-24-1
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PROTAC SMARCA2 degrader-31
0 ImagesCat. No.: HY-168234CAS No.: 2380274-45-1PROTAC SMARCA2-degrader-36 is a PROTAC degrader of SMARCA2, achieving a 99% degradation rate in H929 cells. It also exhibits degradative activity against SMARCA4, but with relatively weaker efficacy. PROTAC SMARCA2-degrader-36 can inhibit cancer cell proliferation and may be used in research related to multiple myeloma.
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DCB29
0 ImagesCat. No.: HY-111575CAS No.: 723245-31-6DCB29 is a selective inhibitor of the BPTF bromodomain, with an IC50 value of 13.2 μM. DCB29 can be used for the study of the BPTF-related diseases (such as bladder cancer, colorectal cancer, melanoma, leukemia, and other cancers).
