WDR5 Inhibitor
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DDO-2093
0 ImagesCat. No.: HY-132233CAS No.: 2250024-74-7DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex.
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MM-589 (racemic mixture ) TFA
0 ImagesCat. No.: HY-100869BPurity: 99.83%MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
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(R)-WM-586
0 ImagesCat. No.: HY-153728APurity: 99.07%(R)-WM-586 is the R-enantiomer of WM-586.
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WDR5-IN-8
0 ImagesCat. No.: HY-161123CAS No.: 3033259-97-8WDR5-IN-8 is a WDR5 inhibitor with IC50 value of 15.5 nM. WDR5-IN-8 shows good anti-proliferative activity in two human acute leukemia cell lines. WDR5-IN-8 has antitumor activity.
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DC_M5_2
0 ImagesCat. No.: HY-183959CAS No.: 713099-37-7
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CS-VIP 8
0 ImagesCat. No.: HY-P10948CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia.
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DD0-2363
0 ImagesCat. No.: HY-168475DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia.
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WDR5-MYC-IN-2
0 ImagesCat. No.: HY-174255CAS No.: 3062125-47-4WDR5-MYC-IN-2 is an inhibitor of WDR5-MYC protein-protein interaction (PPI) with IC50 of 0.59 μM. WDR5-MYC-IN-2 can be studied in research for MYC-driven cancer and development of other effective WDR5-MYC PPI inhibitors.
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MM-401
0 ImagesCat. No.: HY-19554CAS No.: 1442106-10-6MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
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C3TD078
0 ImagesCat. No.: HY-175754C3TD078 is a WDR5 WIN site inhibitor with a Ki of 0.03 nM. C3TD078 has potent antiproliferative activity and reduces the stem-cell frequency of cancer stem cells (CSCs). C3TD078 can be used for glioblastoma (GBM) research.
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WDR5-IN-4 TFA (Standard)
0 ImagesCat. No.: HY-111753ARCAS No.: 2749300-35-2WDR5-IN-4 TFA (Standard) is the analytical standard of WDR5-IN-4 (TFA) (HY-111753A). This product is intended for research and analytical applications. WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity.
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