1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT

Tilapertin (Synonyms: AMG747)

Cat. No.: HY-19887
Handling Instructions

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

For research use only. We do not sell to patients.

Tilapertin Chemical Structure

Tilapertin Chemical Structure

CAS No. : 1000690-85-6

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

IC50 & Target

GlyT1[1]

In Vivo

Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1].

Clinical Trial
References
Molecular Weight

378.39

Formula

C₂₀H₂₁F₃N₂O₂

CAS No.

1000690-85-6

SMILES

O=C(O)CN1CCN([[email protected]](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Tilapertin
Cat. No.:
HY-19887
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Tilapertin

Cat. No.: HY-19887