Afacifenacin
Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB).
For research use only. We do not sell to patients.
- CAS No.: 877606-63-8
- Formula: C27H26F3N3O2
- Molecular Weight:481.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (cerebral infarction model)[2]
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Dosage:0.3, 1, 3 mg/kg
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Administration:Intragastric administration
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Result:Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 877606-63-8
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Molecular Weight 481.51
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Formula C27H26F3N3O2
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SMILES
O=C1NC2=C(C=CC=C2)[C@H](C3=CC=CC=C3)N1C4CCN(CC5=CC=CC(OC(F)(F)F)=C5)CC4
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Synonyms
SMP-986
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Afacifenacin Related Classifications
HY-14828 Related Classifications
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