Afatinib impurity 6

Cat. No.: HY-Z4533 Purity: 96.0%: Data Sheet
COA

SDS
Handling Instructions
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Afatinib impurity 6 is an impurity of Afatinib (HY-10261).

For research use only. We do not sell to patients.

Afatinib impurity 6 Chemical Structure

CAS No. : 1269662-90-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Description

Afatinib impurity 6 is an impurity of Afatinib (HY-10261).

Molecular Weight

332.77

Formula

C₁₆H₁₄ClFN₄O

CAS No.

1269662-90-9

Appearance

Solid

Color

Off-white to yellow

SMILES

NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (75.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0051 mL	15.0254 mL	30.0508 mL
5 mM	0.6010 mL	3.0051 mL	6.0102 mL
10 mM	0.3005 mL	1.5025 mL	3.0051 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.82%

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Data Sheet (243 KB) SDS (393 KB)

COA (249 KB) HNMR (123 KB) LCMS (289 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0051 mL	15.0254 mL	30.0508 mL	75.1270 mL
	5 mM	0.6010 mL	3.0051 mL	6.0102 mL	15.0254 mL
	10 mM	0.3005 mL	1.5025 mL	3.0051 mL	7.5127 mL
	15 mM	0.2003 mL	1.0017 mL	2.0034 mL	5.0085 mL
	20 mM	0.1503 mL	0.7513 mL	1.5025 mL	3.7563 mL
	25 mM	0.1202 mL	0.6010 mL	1.2020 mL	3.0051 mL
	30 mM	0.1002 mL	0.5008 mL	1.0017 mL	2.5042 mL
	40 mM	0.0751 mL	0.3756 mL	0.7513 mL	1.8782 mL
	50 mM	0.0601 mL	0.3005 mL	0.6010 mL	1.5025 mL
	60 mM	0.0501 mL	0.2504 mL	0.5008 mL	1.2521 mL