AGN-745
AGN-745 is a chemically modified siRNA targeted to VEGFR-1. It is used for the study of Macular degeneration.
For research use only. We do not sell to patients.
- CAS No.: 1255908-66-7
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
Description
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1255908-66-7
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SMILES
[AGN-745]
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Synonyms
AGN-211745; Sirna-027
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Purity & Documentation
References
[1]. Jiang J, Zhang X, Tang Y, Li S, Chen J. Progress on ocular siRNA gene-silencing therapy and drug delivery systems. Fundam Clin Pharmacol. 2021;35(1):4-24. [Content Brief]
[2]. Shen J, Samul R, Silva RL, et al. Suppression of ocular neovascularization with siRNA targeted to VEGF receptor 1. Gene Ther. 2006;13(3):225-234. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AGN-745 Related Classifications
HY-177612 Related Classifications
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