AKP-001
AKP-001 is an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK). AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease.
For research use only. We do not sell to patients.
- CAS No.: 897644-83-6
- Formula: C21H13ClF2N4O2
- Molecular Weight:426.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
49.1 nM
Compound: 26d
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Antiinflammatory activity in human THP1 cells assessed as LPS-induced TNFalpha secretion at 15 uM after 2 hrs by ELISA in presence of 10% fetal calf serum
Antiinflammatory activity in human THP1 cells assessed as LPS-induced TNFalpha secretion at 15 uM after 2 hrs by ELISA in presence of 10% fetal calf serum
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[PMID: 24938496] |
Chemical Information
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CAS No. 897644-83-6
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Molecular Weight 426.80
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Formula C21H13ClF2N4O2
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SMILES
O=C(NC1=C(C2=NC=NC=C2)C(C3=CC=C(F)C=C3)=NO1)CC4=C(F)C=CC=C4Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKP-001 Related Classifications
HY-100278 Related Classifications
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