Akt/ROCK-IN-1
Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma.
For research use only. We do not sell to patients.
- CAS No.: 2983889-44-5
- Formula: C21H19BrF2N4O2S
- Molecular Weight:509.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Akt/ROCK-IN-1 (0.5 μM; 0-72 h), shows potent antiproliferative effects and excellent differentiation-inducing activity in Neuro2a cells.[1].
Akt/ROCK-IN-1 (800 nM) can lead to a significant increase in the proportion of Neuro2a cells in G0/G1 phase[1].
Akt/ROCK-IN-1 (0.5, 2 μM) can lead to a significant decrease in the phosphorylation levels of mTOR, GSK-3β, and PRAS40, whereas Akt showed a feedback increase in phosphorylation levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Akt/ROCK-IN-1 (10 mg/kg; i.p., p.o.; Single Dose) with intraperitoneal administration results in better pharmacokinetic parameters compared to oral administration in rats[1].
Pharmacokinetic Analysis in ICR mice Model[1]
| Route | Dose (mg/kg) | Tmax (h) | T1/2 (h) | Cmax (ng/mL) | Cl (mL·h/kg) | AUC0-t (ng·h/mL) | AUC0-∞ (ng·h/mL) | MRT (h) | Vss/Vd (L/kg) |
| p.o. | 10 | 2.0 | 4.3 | 96.3 | 15374.1 | 481.8 | 650.4 | 6.2 | 96 |
| i.p. | 10 | 0.3 | 2.2 | 561.3 | 5934.9 | 1548.9 | 1685.0 | 3.2 | 19.0 |