Alirinetide
Based on 1 Customer Validation
Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 725715-18-4
- Formula: C36H54N12O9
- Molecular Weight:798.89
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Alirinetide (GM604) (0.1-10 mg/mL; 24 h) prevents SH-SY5Y cell death[1].
Alirinetide (48 h) predominantly represses Parkinson’s disease-associated genes in SH-SY5Y cells, these genes were largely associated with the mitochondrial protein complex and respiratory chain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:0.1, 1 or 10 mg/mL
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Incubation Time:24 h
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Result:Led to dose-dependent rescue of cell survival, with complete recovery of cell viability at the highest dose (10 mg/mL).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model[1]
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Dosage:0, 1, 5, 10 or 20 mg/kg
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Administration:Intravenous injection, twice daily for 5 days
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Result:Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 725715-18-4
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Appearance Solid
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Molecular Weight 798.89
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Formula C36H54N12O9
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Color White to off-white
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Synonyms
GM604
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 100 mg/mL (125.17 mM; Need ultrasonic)
DMSO : 100 mg/mL (125.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.2517 mL | 6.2587 mL | 12.5174 mL | 31.2934 mL |
| 5 mM | 0.2503 mL | 1.2517 mL | 2.5035 mL | 6.2587 mL | |
| 10 mM | 0.1252 mL | 0.6259 mL | 1.2517 mL | 3.1293 mL | |
| 15 mM | 0.0834 mL | 0.4172 mL | 0.8345 mL | 2.0862 mL | |
| 20 mM | 0.0626 mL | 0.3129 mL | 0.6259 mL | 1.5647 mL | |
| 25 mM | 0.0501 mL | 0.2503 mL | 0.5007 mL | 1.2517 mL | |
| 30 mM | 0.0417 mL | 0.2086 mL | 0.4172 mL | 1.0431 mL | |
| 40 mM | 0.0313 mL | 0.1565 mL | 0.3129 mL | 0.7823 mL | |
| 50 mM | 0.0250 mL | 0.1252 mL | 0.2503 mL | 0.6259 mL | |
| 60 mM | 0.0209 mL | 0.1043 mL | 0.2086 mL | 0.5216 mL | |
| 80 mM | 0.0156 mL | 0.0782 mL | 0.1565 mL | 0.3912 mL | |
| 100 mM | 0.0125 mL | 0.0626 mL | 0.1252 mL | 0.3129 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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