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United States

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製品番号: HY-14246

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ALK-IN-38

Anaplastic Lymphoma Kinase Inhibitor.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1022957-12-5
分子式: C₂₅H₂₉ClN₆O₃
分子量:496.99

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALK-IN-38 構造式

CAS 番号: 1022957-12-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Anaplastic Lymphoma Kinase Inhibitor

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-299	EC₅₀	200 nM Compound: 15	Growth inhibition of ALK-positive human KARPAS299 cells by MTS assay Growth inhibition of ALK-positive human KARPAS299 cells by MTS assay	[PMID: 24900237]
KARPAS-299	IC₅₀	225 nM Compound: 15	Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma	[PMID: 24900237]
KARPAS-299	IC₅₀	45 nM Compound: 15	Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells	[PMID: 24900237]
KARPAS-299	IC₅₀	45 nM Compound: 3	Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma	[PMID: 22564207]

化学情報

CAS 番号 1022957-12-5
分子量 496.99
分子式 C₂₅H₂₉ClN₆O₃
SMILES

NC([C@H]1[C@@](C=C2)([H])C[C@@]2([H])[C@H]1NC3=NC(NC4=CC=C(N(C(CCC5)=O)CC)C5=C4OC)=NC=C3Cl)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity ACS Med. Chem. Lett., Article ASAP DOI: 10.1021/ml100158s Publication Date (Web): September 1, 2010

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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