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  3. Isotope-Labeled Compounds
  4. Sodium α-ketoisocaproic acid-13C6

Sodium α-ketoisocaproic acid-13C6  (Synonyms: Sodium 4-methyl-2-oxopentanoate-13C6; 2-Ketoisocaproic acid-13C6 sodium salt)

Cat. No.: HY-W017387S2 Assay: 99.3%
COA
SDS
Handling Instructions Technical Support

Sodium α-ketoisocaproic acid-13C6 is the 13C labeled Sodium α-ketoisocaproic acid.

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Sodium α-ketoisocaproic acid-<sup>13</sup>C<sub>6</sub>

Sodium α-ketoisocaproic acid-13C6 화학구조

CAS No. : 2483736-03-2

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg   견적 받기  
10 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Sodium α-ketoisocaproic acid-13C6:

Sodium α-ketoisocaproic acid-13C6 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Sodium α-ketoisocaproic acid-13C6 is the 13C labeled Sodium α-ketoisocaproic acid[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium α-ketoisocaproic acid-13C6 Related Antibodies
분자량

158.08

화학식

13C6H9NaO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[13CH3][13CH]([13CH3])[13CH2][13C]([13C](O[Na])=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

DMSO : 100 mg/mL (632.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3259 mL 31.6296 mL 63.2591 mL
5 mM 1.2652 mL 6.3259 mL 12.6518 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.3%

SDS (252 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.3259 mL 31.6296 mL 63.2591 mL 158.1478 mL
5 mM 1.2652 mL 6.3259 mL 12.6518 mL 31.6296 mL
10 mM 0.6326 mL 3.1630 mL 6.3259 mL 15.8148 mL
15 mM 0.4217 mL 2.1086 mL 4.2173 mL 10.5432 mL
20 mM 0.3163 mL 1.5815 mL 3.1630 mL 7.9074 mL
25 mM 0.2530 mL 1.2652 mL 2.5304 mL 6.3259 mL
30 mM 0.2109 mL 1.0543 mL 2.1086 mL 5.2716 mL
40 mM 0.1581 mL 0.7907 mL 1.5815 mL 3.9537 mL
50 mM 0.1265 mL 0.6326 mL 1.2652 mL 3.1630 mL
60 mM 0.1054 mL 0.5272 mL 1.0543 mL 2.6358 mL
80 mM 0.0791 mL 0.3954 mL 0.7907 mL 1.9768 mL
100 mM 0.0633 mL 0.3163 mL 0.6326 mL 1.5815 mL
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Sodium α-ketoisocaproic acid-13C6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium α-ketoisocaproic acid-13C62483736-03-2Sodium 4-methyl-2-oxopentanoate-13C62-Ketoisocaproic acid-13C6Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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상품명:
Sodium α-ketoisocaproic acid-13C6
Cat. No.:
HY-W017387S2
수량:
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