Ambamustine hydrochloride
Ambamustine (PTT119) hydrochloride is a bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities.
For research use only. We do not sell to patients.
- CAS No.: 83996-50-3
- Formula: C29H40Cl3FN4O4S
- Molecular Weight:666.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 83996-50-3
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Molecular Weight 666.07
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Formula C29H40Cl3FN4O4S
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SMILES
CSCC[C@@H](C(OCC)=O)NC([C@H](CC1=CC=CC(N(CCCl)CCCl)=C1)NC([C@H](CC2=CC=C(F)C=C2)N)=O)=O.Cl
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Synonyms
PTT119 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. M J Yagi, et al. Interference of mouse mammary tumor virus replication by PTT.119 [p-fluoro-L-phe-m-bis-(2-chloroethyl)amino-L-phe-met ethoxy HCl]--an antitumor agent. J Natl Cancer Inst. 1986 Mar;76(3):493-501. [Content Brief]
[2]. A Ardizzoni, et al. Ambamustine in the second-line treatment of patients with small-cell lung cancer: a phase II Fonicap study. Am J Clin Oncol. 2000 Feb;23(1):22-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ambamustine hydrochloride Related Classifications
HY-19577A Related Classifications
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