1. PROTAC
  2. PROTAC Linker
  3. Amino-PEG4-C1-Boc

Amino-PEG4-C1-Boc 

Cat. No.: HY-42619
Handling Instructions

Amino-PEG4-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG4-C1-Boc Chemical Structure

Amino-PEG4-C1-Boc Chemical Structure

CAS No. : 864680-64-8

Size Price Stock Quantity
250 mg USD 465 In-stock
Estimated Time of Arrival: December 31
500 mg USD 650 In-stock
Estimated Time of Arrival: December 31
1 g USD 910 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Amino-PEG4-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

Molecular Weight

307.38

Formula

C₁₄H₂₉NO₆

CAS No.

864680-64-8

SMILES

NCCOCCOCCOCCOCC(OC(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (162.67 mM; Need ultrasonic)

DMSO : 20 mg/mL (65.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2533 mL 16.2665 mL 32.5330 mL
5 mM 0.6507 mL 3.2533 mL 6.5066 mL
10 mM 0.3253 mL 1.6267 mL 3.2533 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (6.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (6.51 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (6.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Amino-PEG4-C1-BocPROTAC LinkerInhibitorinhibitorinhibit

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Product name:
Amino-PEG4-C1-Boc
Cat. No.:
HY-42619
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