Antibacterial agent 141 

Antibacterial agent 141 (Compound B14) has antibacterial activity against four plant pathogens Xoo, Xac, Psa and Cmm, with an EC₅₀ value of 1.28 μM. Antibacterial agent 141 can inhibit the formation of cell membrane and change cell permeability.

Antibacterial agent 141 significantly induces cell membrane rupture in Xoo bacteria^[1].
Antibacterial agent 141 increases bacterial membrane permeability in a concentration-dependent manner in Xoo bacteria^[1].
Antibacterial agent 141 damages the cell membrane surface in Xoo bacteria^[1].
Antibacterial agent 141 (3.2, 6.4 μM) significantly reduces the expression of ACC, ACP and Fab family genes in Xoo bacteria^[1].
Antibacterial agent 141 significantly suppresses the formation of Xoo biofilm with the increase of concentration^[1].
Antibacterial agent 141 is low toxic to HepG2 and HK-2 cell^[1].
Antibacterial agent 141 (0.64-5.12 μM; 3-30 h) significantly inhibits the growth of Xoo bacteria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 141 (200 μg/mL; 7 days; single dose) is 4.64% and 43.33% of curative and protective activity toward bacterial blight, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

414.93

C₂₃H₂₇ClN₂O₃

2930013-56-0

O=C1CC2(OC3=CC=C(C=C13)Cl)CCN(CC2)CC(CNCC4=CC=CC=C4)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu SS, et al. Novel spiro[chromanone-2,4'-piperidine]-4-one derivatives as potential inhibitors of fatty acid synthesis in pathogens: Design, synthesis, and biological evaluation. Eur J Med Chem. 2023 Mar 15;250:115215.  [Content Brief]