Antibacterial agent 58
Antibacterial agent 58, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime.
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- CAS No.: 1426572-65-7
- Formule: C8H11N6NaO5S
- Masse moléculaire:326.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Antibacterial agent 58 (example 23) significantly lowers MIC value of Ceftazidime (MIC=1, 2, 8 mcg/ml for E. coli NCTC 1335 1, E. coli M50, and E. coli 7MP, respectively). Antibacterial agent 58 significantly lowers MIC values of the antibacterial agent Ceftazidime (MIC=0.2~2 mcg/ml for class A ESBL; 2-8 mcg/ml for class C ESBL; 4-8 mcg/ml for KPC ESBL)[1]. From WO2013030735A1, example 23.
Class A ESBL: E.coli W 13353; E.coli W3351; E.coli W 13352
Class C ESBL: E.coli M 50; E.coli 7 MIP; E.coli B 89
KPC ESBL: K.pneumoniae H 520; K.pneumoniae H 521; K. pneumoniae H 522
Class D ESBL: A.Baumannii13301; A.baumannii 13304
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1426572-65-7
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Masse moléculaire 326.26
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Formule C8H11N6NaO5S
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SMILES
O=C1N2[C@@](C3=NN(C)N=N3)([H])CC[C@@H](N1OS(=O)(O[Na])=O)C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 58 Related Classifications
HY-139775 Related Classifications
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