Apoptotic agent-5 

Apoptotic agent-5 is an apoptosis inducer that releases large amounts of nitric oxide to induce cell apoptosis. Apoptotic agent-5 can be used in research related to triple-negative breast cancer^[1].

Apoptotic agent-5 (0.014-2.044 μM; 48 h) potently inhibits the proliferation of MDA-MB-231, MCF-7, BGC-823, and A549 cells, with the highest potency against MDA-MB-231 cells (IC₅₀ = 0.014 μM), and exhibits high selectivity for MDA-MB-231 cells over normal MCF-10A cells (SI = 129.57)^[1].
Apoptotic agent-5 (25 μM; 2 h) releases high levels of intracellular NO in MDA-MB-231 cells, supporting its anti-proliferative mechanism of action^[1].
Apoptotic agent-5 (7-28 nM) induces concentration-dependent apoptosis in MDA-MB-231 cells, with significant increases in both early and late apoptotic cell populations observed at concentrations of 7, 14, and 28 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

644.63

C₂₇H₂₄N₄O₁₁S₂

O=S(C1=[N+]([O-])ON=C1OCCC2=CC=C(OCCCOC3=NO[N+]([O-])=C3S(C4=CC=CC=C4)(=O)=O)C=C2)(C5=CC=CC=C5)=O

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• [1]. Zhang B, et al. New salidroside-furoxan hybrids as potential agents inhibit triple-negative breast cancer. Bioorg Med Chem Lett. 2026;136:130627.  [Content Brief]