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Cat. No.: HY-151038

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AR ligand-22

AR ligand-22 (ABM-1) is a PROTAC target protein ligand. AR ligand-22 can be used to synthesize PROTAC AR Degrader-32 (HY-191214).

For research use only. We do not sell to patients.

CAS No.: 1973408-67-1
Formula: C₁₈H₁₄ClN₃O₂S
Molecular Weight:371.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

AR ligand-22 Chemical Structure

CAS No.: 1973408-67-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

AR ligand-22 (ABM-1) is a PROTAC target protein ligand. AR ligand-22 can be used to synthesize PROTAC AR Degrader-32 (HY-191214).

In Vitro

PROTAC molecules consist of a target protein ligand and an E3 ubiquitin ligase ligand, which are joined together by a linker. The target protein ligand causes the PROTAC to attach to the target protein for ubiquitination and subsequent degradation.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1973408-67-1
Molecular Weight 371.84
Formula C₁₈H₁₄ClN₃O₂S
SMILES

CC1(C(N(C(N1C2=CC=C(C=C2)O)=S)C3=CC=C(C(Cl)=C3)C#N)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1. 2017-07-20.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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