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Cat. No.: HY-190697

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AR ligand-53

AR ligand-53 is a ligand of the androgen receptor. AR ligand-53 can serve as a target protein ligand for the synthesis of PROTACs, such as PROTAC AR Degrader-24 (HY-190696). AR ligand-53 can be used for research on prostate cancer.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₇F₃N₆O₃
Molecular Weight:422.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

AR ligand-53 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

PROTAC stands for proteolysis-targeting chimeras, a type of heterobifunctional small-molecule compound whose structure contains two different ligands: one is a ubiquitin ligase E3 ligand, and the other is a ligand that binds to the target protein in cells. The two ligands are connected by a linker, thereby forming a "ternary" polymer-target protein ligand-Linker-E3 ligand. PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and the intracellular E3 ubiquitin ligase closer together. PROTACs can improve the druggability of "undruggable" targets.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

Chemical Information

Molecular Weight 422.36
Formula C₁₈H₁₇F₃N₆O₃
SMILES

O=C(C1=CN=C(O)C=C1)NC2CCC(OC3=NN4C(C=C3)=NN=C4C(F)(F)F)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fu CW, et al. Androgen receptor binding bifunctional molecules. European patent EP 4023649 A1. Published 2022 Jul 06.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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