AS3513678
AS3513678 is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3513678 promotes acetylcholine (ACh) signaling via m-nAChR, shifts the ACh concentration-response curve to the left, and does not activate the receptor in the absence of ACh. AS3513678 can be used for research on myasthenia gravis and congenital myasthenic syndrome.
For research use only. We do not sell to patients.
- Formula: C26H17F4N3O4S2
- Molecular Weight:575.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AS3513678 (1-10 μM) acts as a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptors in differentiated Hu5/KD3 human myotubes, reducing the EC50 of ACh by 7.8-fold at a concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 575.55
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Formula C26H17F4N3O4S2
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SMILES
FC1=CC(C2=C(C(F)(F)F)N=C(NC(C(N3C)=C(O)C4=C(C=CC=C4)S3(=O)=O)=O)S2)=CC=C1C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS3513678 Related Classifications
HY-188045 Related Classifications
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