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United States

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Referencia número: HY-188046

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AS3566987

AS3566987 is a positive allosteric modulator of the skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3566987 promotes acetylcholine signaling via the skeletal muscle-type nicotinic acetylcholine receptor, and receptor activation requires the involvement of acetylcholine. AS3566987 can be used in the research of neuromuscular diseases (including myasthenia gravis and congenital myasthenic syndrome).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₄H₁₆F₃N₅O₅S₂
Peso molecular:575.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

AS3566987 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

AS3566987 (10 μM) acts as a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptors in Hu5/KD3 human myotubes, reducing the EC₅₀ of ACh by 10.4-fold without inducing currents in the absence of ACh^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 575.54
Fòrmula C₂₄H₁₆F₃N₅O₅S₂
SMILES

FC(F)(F)C(N=C(NC(C(N1C)=C(O)C2=C(C=C(O)C=C2)S1(=O)=O)=O)S3)=C3C(C=N4)=CN=C4C5=CC=CC=C5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Saito A, et al. Discovery and pharmacological characterization of novel positive allosteric modulators acting on skeletal muscle-type nicotinic acetylcholine receptors. Biochemical and biophysical research communications. 2023 Aug 06;668:27-34.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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