Centanafadine
Based on 1 Customer Validation
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
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- Reinheit: 99.62%
- CAS. Nr.: 924012-43-1
- Formel: C15H15N
- Molecular Weight:209.29
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
IC50: 6 nM (human NE), 38 nM (human DA), 83 nM (human serotonin)[1].
Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters with IC50 values of 6 and 38 nM, respectively, for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT with an IC50 value of 83 nM [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 924012-43-1
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Appearance Solid
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Molecular Weight 209.29
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Formel C15H15N
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Color White to off-white
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SMILES
[C@@H]12[C@@](CNC2)(C3=CC(C=CC=C4)=C4C=C3)C1
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Synonyms
EB-1020
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (597.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7781 mL | 23.8903 mL | 47.7806 mL | 119.4515 mL |
| 5 mM | 0.9556 mL | 4.7781 mL | 9.5561 mL | 23.8903 mL | |
| 10 mM | 0.4778 mL | 2.3890 mL | 4.7781 mL | 11.9451 mL | |
| 15 mM | 0.3185 mL | 1.5927 mL | 3.1854 mL | 7.9634 mL | |
| 20 mM | 0.2389 mL | 1.1945 mL | 2.3890 mL | 5.9726 mL | |
| 25 mM | 0.1911 mL | 0.9556 mL | 1.9112 mL | 4.7781 mL | |
| 30 mM | 0.1593 mL | 0.7963 mL | 1.5927 mL | 3.9817 mL | |
| 40 mM | 0.1195 mL | 0.5973 mL | 1.1945 mL | 2.9863 mL | |
| 50 mM | 0.0956 mL | 0.4778 mL | 0.9556 mL | 2.3890 mL | |
| 60 mM | 0.0796 mL | 0.3982 mL | 0.7963 mL | 1.9909 mL | |
| 80 mM | 0.0597 mL | 0.2986 mL | 0.5973 mL | 1.4931 mL | |
| 100 mM | 0.0478 mL | 0.2389 mL | 0.4778 mL | 1.1945 mL |
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