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Art. -Nr.: HY-103067

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A1899

(Synonyms: S20951)

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A1899 is a potent and highly selective blocker of the K_2P channel TASK-1. A1899 has IC₅₀ values of 35.1 nM and 7 nM for TASK-1 channels expressed in oocytes and CHO cells, respectively. A1899 is also an I_Kur blocker that can be used for the research of cardiovascular diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.72%
CAS. Nr.: 498577-46-1
Formel: C₃₀H₂₆F₂N₂O₃
Molecular Weight:500.54

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

A1899 Chemical Structure

CAS. Nr.: 498577-46-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

TASK-1

0.035 μM (IC₅₀)

TASK-3

0.318 pg/mL (IC₅₀)

TASK-2

12 μM (IC₅₀)

TASK-4

8.1 μM (IC₅₀)

TREK-1

23.8 μM (pIC₅₀)

TREK-2

8.4 μM (IC₅₀)

TRAAK

>20 μM (IC₅₀)

THIK-1

2.2 μM (IC₅₀)

TRESK

0.9 μM (IC₅₀)

Kv1.1

2.7 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.007 μM Compound: 1; A1899	Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay	[PMID: 31260312]
CHO	IC₅₀	0.07 μM Compound: 1; A1899	Inhibition of human TASK3 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay Inhibition of human TASK3 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay	[PMID: 31260312]
CHO	IC₅₀	12 μM Compound: 1; A1899	Inhibition of human TASK2 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay Inhibition of human TASK2 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay	[PMID: 31260312]
CHO	IC₅₀	7 nM Compound: 1, A-1899	Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay	[PMID: 25017033]
CHO	IC₅₀	8.1 μM Compound: 1; A1899	Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay	[PMID: 31260312]
Oocyte	IC₅₀	1.2 μM Compound: 17m	Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes	[PMID: 12570371]

Chemical Information

CAS. Nr. 498577-46-1
Appearance Solid
Molecular Weight 500.54
Formel C₃₀H₂₆F₂N₂O₃
Color Off-white to light yellow
SMILES

O=C(NCC1=CC=C(C=C1F)F)C2=CC=CC=C2C3=CC=CC=C3CNC(CC4=CC=C(C=C4)OC)=O
Synonyms

S20951
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (249.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9978 mL

9.9892 mL

19.9784 mL

5 mM

0.3996 mL

1.9978 mL

3.9957 mL

10 mM

0.1998 mL

0.9989 mL

1.9978 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Streit AK, et al. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem. 2011 Apr 22;286(16):13977-84. [Content Brief]

[2]. Knobloch K, et al. Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):482-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9978 mL	9.9892 mL	19.9784 mL	49.9461 mL
	5 mM	0.3996 mL	1.9978 mL	3.9957 mL	9.9892 mL
	10 mM	0.1998 mL	0.9989 mL	1.9978 mL	4.9946 mL
	15 mM	0.1332 mL	0.6659 mL	1.3319 mL	3.3297 mL
	20 mM	0.0999 mL	0.4995 mL	0.9989 mL	2.4973 mL
	25 mM	0.0799 mL	0.3996 mL	0.7991 mL	1.9978 mL
	30 mM	0.0666 mL	0.3330 mL	0.6659 mL	1.6649 mL
	40 mM	0.0499 mL	0.2497 mL	0.4995 mL	1.2487 mL
	50 mM	0.0400 mL	0.1998 mL	0.3996 mL	0.9989 mL
	60 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8324 mL
	80 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL
	100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.4995 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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A1899

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

A1899 Related Classifications

HY-103067 Related Classifications