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Art. -Nr.: HY-144125

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Antitumor agent-41

Antitumor agent-41 (compound N-12), a potent antitumor agent, enhibits excellent antimigration and anti-invasion activity. Antitumor agent-41 (compound N-12) induces tumor inhibition via tumor necrosis and inflammatory response.

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CAS. Nr.: 3035564-55-4
Formel: C₆₄H₁₀₉IN₂O₂₁
Molecular Weight:1369.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antitumor agent-41 Chemical Structure

CAS. Nr.: 3035564-55-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	>200 μM Compound: N-12	Cytotoxicity against human A-431 cells measured after 24 hrs by MTT assay Cytotoxicity against human A-431 cells measured after 24 hrs by MTT assay	[PMID: 35073068]
CHO	IC₅₀	>200 μM Compound: N-12	Cytotoxicity against CHO cells measured after 24 hrs by MTT assay Cytotoxicity against CHO cells measured after 24 hrs by MTT assay	[PMID: 35073068]
HeLa	IC₅₀	>200 μM Compound: N-12	Cytotoxicity against human HeLa cells measured after 24 hrs by MTT assay Cytotoxicity against human HeLa cells measured after 24 hrs by MTT assay	[PMID: 35073068]
N2a	IC₅₀	>200 μM Compound: N-12	Cytotoxicity against mouse Neuro2a cells measured after 24 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells measured after 24 hrs by MTT assay	[PMID: 35073068]
PC-12	IC₅₀	>200 μM Compound: N-12	Cytotoxicity against rat PC-12 cells measured after 24 hrs by MTT assay Cytotoxicity against rat PC-12 cells measured after 24 hrs by MTT assay	[PMID: 35073068]

In Vitro

Antitumor agent-41 (compound N-12) has obvious inhibitory activity on invasion at a concentration of 50 μM on A431 cell, and the inhibition rate was 36.6 ± 13.9% ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The half-life (T_1/2) of antitumor-41 (compound N-12) is 56.80 h and systemic plasma clearance (CL) is 0.029 mL/h/mg.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3035564-55-4
Molecular Weight 1369.46
Formel C₆₄H₁₀₉IN₂O₂₁
SMILES

O[C@@H]1[C@@H]([C@H]([C@@H](O[C@@H]1CO)O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2CO)OC[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC(CCCCCCCCCCCCCCCCC)=O)O)O)O)O[C@@]3(C[C@@H]([C@H]([C@@H](O3)[C@@H]([C@@H](CO)O)O)NC(C4=CC(I)=CC=C4)=O)O)C(O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Juntao Wang, wt al. One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics. J Med Chem. 2022 Feb 10;65(3):1883-1897. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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