BiCAPPA
Based on 1 Customer Validation
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.35%
- CAS. Nr.: 119662-55-4
- Formel: C38H40Cl2N6O2
- Molecular Weight:683.67
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | EC50 |
1480 nM
Compound: 9
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Cytotoxicity against human HL60 cells
Cytotoxicity against human HL60 cells
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[PMID: 17371810] |
BiCAPPA (10 nM-2 μM; 5 d) decreases proteinase K-resistant PrPSc from scrapie-infected mouse hypothalamus cells, with an EC50 of 0.32 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 119662-55-4
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Appearance Solid
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Molecular Weight 683.67
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Formel C38H40Cl2N6O2
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Color Yellow to orange
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SMILES
ClC(C=CC1=C2NCCCN3CCN(CCCNC4=C5C=CC(Cl)=CC5=NC6=C4C=C(OC)C=C6)CC3)=CC1=NC7=C2C=C(OC)C=C7
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 9.52 mg/mL (13.92 mM; ultrasonic and adjust pH to 4 with TFA; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.4627 mL | 7.3135 mL | 14.6269 mL | 36.5674 mL |
| 5 mM | 0.2925 mL | 1.4627 mL | 2.9254 mL | 7.3135 mL | |
| 10 mM | 0.1463 mL | 0.7313 mL | 1.4627 mL | 3.6567 mL |
BiCAPPA Related Classifications
HY-138865 Related Classifications
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