119662-55-4
119662-55-4
Chemical Structure
BiCAPPA
- CAS No.: 119662-55-4
- Formula:C38H40Cl2N6O2
- Molecular Weight:683.67
IUPAC Name: N,N'-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(6-chloro-2-methoxyacridin-9-amine)
InChIKey: GUTKNTSGEOMFPZ-UHFFFAOYSA-N
SMILES: ClC(C=CC1=C2NCCCN3CCN(CCCNC4=C5C=CC(Cl)=CC5=NC6=C4C=C(OC)C=C6)CC3)=CC1=NC7=C2C=C(OC)C=C7
Biological Activity: BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BiCAPPA | 98.35% | BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM. | ||||||||||||||||||||
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References
- [1]. Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277.
- [2]. Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201. [Content Brief]
Keywords
