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Art. -Nr.: HY-N19744

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(-)-Calanolide B

(-)-Calanolide B is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC₅₀ of 0.5 mM against HIV-1 RT. (-)-Calanolide B inhibits the replication of HIV-1 IIIb/LAV. (-)-Calanolide B is applicable to research related to HIV-1 infection.

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CAS. Nr.: 909-14-8
Formel: C₂₂H₂₆O₅
Molecular Weight:370.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Calanolide B Chemical Structure

CAS. Nr.: 909-14-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

HIV-1 RT

0.5 mM (IC₅₀)

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	18.7 μM Compound: (-)-1	Anti-HIV activity against HIV-I RFII strain in CEM cell line Anti-HIV activity against HIV-I RFII strain in CEM cell line	[PMID: 8632437]
CEM-SS	EC₅₀	0.2 μM Compound: 2	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	5.9 μM Compound: 2	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	0.2 μM Compound: (-)-Calanolide B	Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 11430019]
H9	EC₅₀	0.22 μM Compound: 13	Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay	[PMID: 8792623]
H9	IC₅₀	9.8 μM Compound: 13	Cytotoxicity against human H9 cells Cytotoxicity against human H9 cells	[PMID: 8792623]
MT2	IC₅₀	5.89 μM Compound: (-)-1	Anti-HIV activity against HIV-I A17 strain in MT2 cell line Anti-HIV activity against HIV-I A17 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.16 μM Compound: (-)-1	Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.21 μM Compound: (-)-1	Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	7.31 μM Compound: (-)-1	Anti-HIV activity against HIV-I IIIB strain in MT2 cell line Anti-HIV activity against HIV-I IIIB strain in MT2 cell line	[PMID: 8632437]

In Vitro

(-)-Calanolide B (Compound 7) at 1 mM potently inhibits HIV-1 RT, with an IC₅₀ of 0.5 mM and an inhibition rate of 76.2% at 1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 909-14-8
Molecular Weight 370.44
Formel C₂₂H₂₆O₅
SMILES

CCCC(C1=C(O2)C3=C(O[C@H]([C@@H]([C@@H]3O)C)C)C4=C1OC(C)(C=C4)C)=CC2=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Signal Pathway Related

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Huerta-Reyes M, Basualdo Mdel C, Abe F, et al.. HIV-1 inhibitory compounds from Calophyllum brasiliense leaves. Biological & pharmaceutical bulletin. 2004 Sep;27(9):1471-5. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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