Art. -Nr.: HY-B1580

Calcium propionate

Name: Calcium propionate
Brand: MedChemExpress
SKU: HY-B1580
Price: 25.00 USD
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(Synonyms: Propionic acid calcium)

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Calcium propionate (Propionic acid calcium) is a calcium salt of Propionic acid with oral activity, which can be hydrolyzed into propionate and calcium ions. Calcium propionate elevates intracellular ROS levels in tumor cells, depletes GSH, reduces mitochondrial membrane potential, and thereby induces tumor cell apoptosis. In mouse colitis models, Calcium propionate modulates inflammatory factors such as IFN-γ, calprotectin, and Pglyrp3, ameliorating intestinal inflammation and metabolic disorders. In ruminants, Calcium propionate serves as a gluconeogenic precursor, regulating rumen fermentation and microbial diversity; in high-fat diet rats, it alters gut microbiota composition and affects blood biochemical parameters. Calcium propionate is commonly used as a food and feed additive, and is also used in research related to hypocalcemia, dyslipidemia, colitis, and lung cancer.

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Reinheit : 99.0%
CAS. Nr.: 4075-81-4
Formel: (CH₃CH₂COO)2Ca
Molecular Weight:186.22

Speicherung:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

Calcium propionate Chemical Structure

CAS. Nr.: 4075-81-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC50	5.44 mg/mL	Cytotoxicity against human A549 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay. Cytotoxicity against human A549 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay.	tjb-2024-0054
DMS-114	IC50	12.15 mg/mL	Cytotoxicity against human DMS114 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay. Cytotoxicity against human DMS114 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay.	tjb-2024-0054

In Vitro

Anti-cancerApoptosisOxidative StressMitochondrial Function

Anti-cancer

Calcium propionate (0-16 mg/mL; 24 h) exerts dose-dependent cytotoxic effects on A549 lung cancer cells with an IC₅₀ of 5.44 mg/mL, and inhibits DMS114 cells with an IC₅₀ of 12.15 mg/mL, whereas Beas-2B normal lung cells maintain viability above 70% at all tested concentrations^[5].

Anti-cancer

Apoptosis

Oxidative Stress

Calcium propionate (0-16 mg/mL; 24 h) increases intracellular ROS levels, with the most significant effect observed in A549 cells^[5].

Anti-cancer

Oxidative Stress

Calcium propionate (0.25-16 mg/mL; 24 h) significantly reduces intracellular GSH levels in A549 and DMS114 lung cancer cells, with the greatest reduction observed in A549 cells^[5].

Anti-cancer

Mitochondrial Function

Calcium propionate (0.25-8 mg/mL; 24 h) significantly reduces the mitochondrial membrane potential in A549 and DMS114 lung cancer cells, with the greatest reduction observed in A549 cells^[5].

Anti-cancer

Apoptosis

Calcium propionate (0.25-8 mg/mL; 24 h) induces apoptosis in a dose-dependent manner, with the highest apoptosis rate observed in A549 lung cancer cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Calcium propionate (200-500 g/day; p.o.; three times daily; from calving to day 35 postpartum) improves rumen fermentation and secondarily improves rumen bacterial diversity, but has no significant effect on the composition of the major rumen bacterial community in early-lactation dairy cows^[1].
Calcium propionate (0.5-2.0% of food weight; p.o.; daily; 20 days) decreases relative spleen weight and increases relative kidney weight, induces moderate dyslipidemia and elevated De Ritis and Ca/P ratios, and significantly disrupts the gut microbiota by reducing Bifidobacterium and Lactobacillus while promoting Clostridium, Enterococcus, Klebsiella, and Candida, with antibacterial activity against Staphylococcus aureus^[2].
Calcium propionate (100-300 g; p.o.; daily; from parturition to 63 days postpartum) improves the energy status of early-lactation dairy cows, with an optimal dose of approximately 200 g per cow per day^[3].
Calcium propionate (3.85% w/v; drinking water; free access; 7 days) alleviates DSS-induced colitis in C57BL/6 mice, reduces liver weight, liver-to-body weight ratio, and abdominal fat, and decreases plasma IFN-γ and fecal calprotectin, while enhancing Pglyrp3^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS. Nr. 4075-81-4
Appearance Solid
Molecular Weight 186.22
Formel (CH₃CH₂COO)2Ca
Color White to off-white
SMILES

CCC(O[Ca]C1(CC)OO1)=O
Synonyms

Propionic acid calcium
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : ≥ 100 mg/mL (537.00 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.3700 mL

26.8500 mL

53.6999 mL

5 mM

1.0740 mL

5.3700 mL

10.7400 mL

10 mM

0.5370 mL

2.6850 mL

5.3700 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (615 KB)
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- Français - FR (615 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang F, et al. Calcium Propionate Supplementation Has Minor Effects on Major Ruminal Bacterial Community Composition of Early Lactation Dairy Cows. Frontiers in microbiology. 2022;13:847488.

[2]. Lieshchova M A. Effect of calcium propionate on rats with a high-fat hypercaloric diet. Regulatory Mechanisms in Biosystems, 2023, 14(4): 680-686.

[3]. Liu Q, et al. Effects of calcium propionate supplementation on lactation performance, energy balance and blood metabolites in early lactation dairy cows. Journal of animal physiology and animal nutrition. 2010 Oct;94(5):605-14. [Content Brief]

[4]. Ghadimi D, et al. Calcium Propionate Alleviates DSS-Induced Colitis and Influences Lipid Profile, Interferon Gamma, Peptidoglycan Recognition Protein 3 and Calprotectin in One-Year-Old Female and Male C57BL/6 Mice. Scientific Journal of Immunology & Immunotherapy, 2017, 2(1): 007-010.

[5]. Okkay T M. Impact of calcium propionate on cellular behavior in A549 and DMS114 lung cancer cell lines. Turkish Journal of Biochemistry, 2024, 49: 666-673.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.3700 mL	26.8500 mL	53.6999 mL	134.2498 mL
	5 mM	1.0740 mL	5.3700 mL	10.7400 mL	26.8500 mL
	10 mM	0.5370 mL	2.6850 mL	5.3700 mL	13.4250 mL
	15 mM	0.3580 mL	1.7900 mL	3.5800 mL	8.9500 mL
	20 mM	0.2685 mL	1.3425 mL	2.6850 mL	6.7125 mL
	25 mM	0.2148 mL	1.0740 mL	2.1480 mL	5.3700 mL
	30 mM	0.1790 mL	0.8950 mL	1.7900 mL	4.4750 mL
	40 mM	0.1342 mL	0.6712 mL	1.3425 mL	3.3562 mL
	50 mM	0.1074 mL	0.5370 mL	1.0740 mL	2.6850 mL
	60 mM	0.0895 mL	0.4475 mL	0.8950 mL	2.2375 mL
	80 mM	0.0671 mL	0.3356 mL	0.6712 mL	1.6781 mL
	100 mM	0.0537 mL	0.2685 mL	0.5370 mL	1.3425 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Calcium propionate