Art. -Nr.: HY-165529

Camostat

45 Cited Publications

Kundenbewertung

Based on 45 publication(s) in Google Scholar

Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.42%
CAS. Nr.: 59721-28-7
Formel: C₂₀H₂₂N₄O₅
Molecular Weight:398.41

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Camostat Chemical Structure

CAS. Nr.: 59721-28-7

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Publications (45)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-3	CC₅₀	>500 mM Compound: Camostat	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 37284689]
Calu-3	CC₅₀	200 μM Compound: Camostat	Cytotoxicity against human Calu-3 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay Cytotoxicity against human Calu-3 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay	[PMID: 34273661]
Calu-3	CC₅₀	230 nM Compound: Camostat	Cytotoxicity against human Calu-3 cells Cytotoxicity against human Calu-3 cells	[PMID: 39004019]
HEK293	IC₅₀	12.7 μM Compound: camostat	Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	[PMID: 23241029]
HEK293	IC₅₀	16.5 μM Compound: camostat	Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay	[PMID: 23241029]
HEK293	IC₅₀	2.9 μM Compound: camostat	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	[PMID: 23241029]
Sf9	IC₅₀	32 μM Compound: 7	Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to cromogenic substrate addition by spectrophotometry Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to cromogenic substrate addition by spectrophotometry	[PMID: 25882520]
Vero	CC₅₀	>50 μM Compound: Camostat	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	IC₅₀	>50 μM Compound: Camostat	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730

Chemical Information

CAS. Nr. 59721-28-7
Appearance Solid
Molecular Weight 398.41
Formel C₂₀H₂₂N₄O₅
Color White to off-white
SMILES

O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(OCC(N(C)C)=O)=O)C=C2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (45)

All WBBio/Physico-chemical AssayRT-PCR

Sort by:

Journal Impact Factor

Signal Transduct Target Ther

ACE2-independent infection of T lymphocytes by SARS-CoV-2. [Abstract]

2022 Mar 11;7(1):83. PMID: 35277473

Camostat purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Mar 11;7(1):83. [Abstract]

Camostat mesylate (2-20 μM; 1 h) inhibited SARS-CoV-2 infection of Caco2 cells in a dose-dependent manner.
Nature

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. [Abstract]

2022 Mar;603(7902):693-699. PMID: 35062016

Camostat purchased from MedChemExpress. Usage Cited in: Nature. 2022 Mar;603(7902):693-699. [Abstract]

VeroE6-TMPRSS2 cells were pretreated with Camostat mesylate (1–50 μM; 2 h) followed by transduction with pseudoviruses carrying the spike protein of SARS-CoV-2 WT, Alpha, Beta, Delta, or Omicron. Pseudovirus entry was quantified by measuring the luciferase signal of the cell lysates at 24 h.p.i.

Camostat purchased from MedChemExpress. Usage Cited in: Nature. 2022 Mar;603(7902):693-699. [Abstract]

VeroE6-TMPRSS2 cells were pretreated with Camostat mesylate (1-50 μM; 2 h) and challenged with the indicated authentic SARS-CoV-2 variants at 0.1 m.o.i.. The amount of viral subgenomic envelope RNA in the collected cell lysates at 24 h.p.i. was determined using RT–qPCR.
Cell

A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry. [Abstract]

2023 Feb 16;186(4):850-863.e16. PMID: 36803605
Nat Microbiol

HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor. [Abstract]

2025 Nov;10(11):2860-2874. PMID: 41168429

Camostat purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2025 Nov;10(11):2860-2874. [Abstract]

TMPRSS2 inhibitor Camostat mesylate (66.7 μM; 1 h; 37 ℃) dose-dependently inhibited pseudovirus entry of HKU25 clade or HKU5-1 in Caco-2 cells overexpressing the indicated ACE2s.
Nat Microbiol

Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification. [Abstract]

2024 Sep;9(9):2383-2394. PMID: 39179693

Camostat purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2024 Sep;9(9):2383-2394. [Abstract]

TMPRSS2 inhibitor Camostat mesylate (0.01-100 μM) inhibited the WT pseudovirus approximately 3-fold better than the ΔFCS pseudovirus in VeroE6 cells overexpressing hACE2 and TMPRSS2 (VAT cells).
Nat Commun

Pathogenicity, virological features, and immune evasion of SARS-CoV-2 JN.1-derived variants including JN.1.7, KP.2, KP.3, and KP.3.1.1. [Abstract]

2025 Dec 11;16(1):11002. PMID: 41381428
Nat Commun

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses. [Abstract]

2025 Jul 7;16(1):6241. PMID: 40624080
Nat Commun

Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3. [Abstract]

2024 Oct 9;15(1):8728. PMID: 39379369
Nat Commun

Recreating the biological steps of viral infection on a cell-free bioelectronic platform to profile viral variants of concern. [Abstract]

2024 Jul 3;15(1):5606. PMID: 38961055
Nat Commun

Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions. [Abstract]

2022 Jul 26;13(1):4331. PMID: 35882856
Nat Commun

RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection. [Abstract]

2022 Mar 17;13(1):1444. PMID: 35301316
Nat Chem Biol

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. [Abstract]

2022 Sep;18(9):963-971. PMID: 35676539
Nucleic Acids Res

COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. [Abstract]

2021 Jan 8;49(D1):D1113-D1121. PMID: 33166390
Sci Adv

Altered host protease determinants for SARS-CoV-2 Omicron. [Abstract]

2023 Jan 20;9(3):eadd3867. PMID: 36662861
Cell Discov

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells. [Abstract]

2021 Dec 14;7(1):119. PMID: 34903715
EBioMedicine

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5. [Abstract]

2023 Sep:95:104753. PMID: 37579626
Cell Rep Med

Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2. [Abstract]

2022 Sep 20;3(9):100743. PMID: 36084644
Sci China Life Sci

Receptor affinity-selective differential dynamics of membrane fusion initiation govern deltacoronavirus cross-species transmission. [Abstract]

2025 Oct 24. PMID: 41144156
Proc Natl Acad Sci U S A

SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. [Abstract]

2022 Jan 25;119(4):e2117576119. PMID: 35022217
Emerg Microbes Infect

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2. [Abstract]

2022 Dec;11(1):2275-2287. PMID: 36039901
Sci Signal

The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation. [Abstract]

2024 Aug 20;17(850):eadn3785. PMID: 39163389
Eur J Med Chem

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2. [Abstract]

2021 Nov 15:224:113683. PMID: 34273661
Cell Prolif

LL-37 Inhibits TMPRSS2-Mediated S2' Site Cleavage and SARS-CoV-2 Infection but Not Omicron Variants. [Abstract]

2025 May 15:e70060. PMID: 40375579
Biochem Pharmacol

Harringtonine: A more effective antagonist for Omicron variant. [Abstract]

2023 Jul:213:115617. PMID: 37211174
PLoS Pathog

UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein. [Abstract]

2025 Oct 14;21(10):e1013593. PMID: 41086194
Eur J Pharmacol

Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene. [Abstract]

2023 Jan 5:938:175394. PMID: 36403685
mBio

ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells. [Abstract]

2022 Dec 20;13(6):e0256622. PMID: 36409074
Eur J Pharmacol

Mechanisms of NMDA receptor inhibition by nafamostat, gabexate and furamidine. [Abstract]

2022 Mar 15:919:174795. PMID: 35122868
Antiviral Res

Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2. [Abstract]

2023 Jun:214:105606. PMID: 37076089
J Virol

Disruption of spike protein N-glycosylation induces its endoplasmic reticulum retention and attenuates SARS-CoV-2 infectivity. [Abstract]

2026 Apr 21;100(4):e0027026. PMID: 41910405
J Virol

Bovine coronavirus enters HRT-18 cells via membrane fusion and clathrin-mediated endocytosis in a low pH-, dynamin-, cholesterol-, microtubule-, Rab7-, and Rab11-dependent manner. [Abstract]

2025 Nov 18:e0127425. PMID: 41251346
J Virol

Cathepsin L and transmembrane serine protease 11E mediate trypsin-independent entry of porcine deltacoronavirus into Huh7 cells. [Abstract]

2025 Aug 11:e0105525. PMID: 40787987
J Virol

Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine. [Abstract]

2023 May 31;97(5):e0032423. PMID: 37042750
Viruses

Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19. [Abstract]

2022 Feb 8;14(2):353. PMID: 35215943
Am J Physiol Renal Physiol

Control of ENaC ubiquitination. [Abstract]

2024 Aug 1;327(2):F265-F276. PMID: 38867672
Biosaf Health

Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles. [Abstract]

2022 Feb;4(1):38-44. PMID: 35005601
bioRxiv

2026 May 7.
Res Sq

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo. [Abstract]

2024 Nov 21:rs.3.rs-5454588. PMID: 39606435
SSRN

2024 Jul 11.
SSRN

2024 Jan 26.
Res Sq

SARS-CoV-2 Bottlenecks and Tissue-Specific Adaptation in the Central Nervous System. [Abstract]

2023 Sep 11:rs.3.rs-3220157. PMID: 37790412
Utrecht University

2022 Jul.
Research Square Preprint

2022 Jan.
Universidade de São Paulo

2020 Sep.
SSRN

2020 Jun.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 175 mg/mL (439.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5100 mL

12.5499 mL

25.0998 mL

5 mM

0.5020 mL

2.5100 mL

5.0200 mL

10 mM

0.2510 mL

1.2550 mL

2.5100 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Emori Y, et al. Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats. J Gastroenterol Hepatol. 2005 Jun;20(6):895-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5100 mL	12.5499 mL	25.0998 mL	62.7494 mL
	5 mM	0.5020 mL	2.5100 mL	5.0200 mL	12.5499 mL
	10 mM	0.2510 mL	1.2550 mL	2.5100 mL	6.2749 mL
	15 mM	0.1673 mL	0.8367 mL	1.6733 mL	4.1833 mL
	20 mM	0.1255 mL	0.6275 mL	1.2550 mL	3.1375 mL
	25 mM	0.1004 mL	0.5020 mL	1.0040 mL	2.5100 mL
	30 mM	0.0837 mL	0.4183 mL	0.8367 mL	2.0916 mL
	40 mM	0.0627 mL	0.3137 mL	0.6275 mL	1.5687 mL
	50 mM	0.0502 mL	0.2510 mL	0.5020 mL	1.2550 mL
	60 mM	0.0418 mL	0.2092 mL	0.4183 mL	1.0458 mL
	80 mM	0.0314 mL	0.1569 mL	0.3137 mL	0.7844 mL
	100 mM	0.0251 mL	0.1255 mL	0.2510 mL	0.6275 mL

Keywords

Camostat

45 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Camostat

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Orally Active Compound Library

Coagulation and Anti-coagulation Compound Library

Protease Inhibitor Library

Serine/Threonine Kinase Inhibitor Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Camostat

Biologische Aktivität

Chemical Information

Publications (45)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Camostat

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Orally Active Compound Library

Coagulation and Anti-coagulation Compound Library

Protease Inhibitor Library

Serine/Threonine Kinase Inhibitor Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Camostat

Biologische Aktivität

Chemical Information

Publications (45)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Camostat Related Classifications

HY-165529 Related Classifications