Chlorasquin
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents.
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- CAS. Nr.: 18921-73-8
- Formel: C20H19ClN6O5
- Molecular Weight:458.86
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 18921-73-8
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Molecular Weight 458.86
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Formel C20H19ClN6O5
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SMILES
O=C(C[C@H](NC(C1=CC=C(C=C1)NCC2=C(C3=C(N=C(N=C3C=C2)N)N)Cl)=O)C(O)=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Chello PL, et al. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36(7 PT 1):2442-9. [Content Brief]
[2]. Hynes J B, et al. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids[J]. Journal of Medicinal Chemistry, 1977, 20(4): 588-591. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Chlorasquin Related Classifications
HY-121256 Related Classifications
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