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Art. -Nr.: HY-129379

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DC0-NH2

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DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.

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CAS. Nr.: 615538-51-7
Formel: C₃₁H₂₄ClN₅O₃
Molecular Weight:550.01

Speicherung:

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

DC0-NH2 Chemical Structure

CAS. Nr.: 615538-51-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Duocarmycins

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	30 pM Compound: 22, C0-NH2	Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
NAMALVA	IC₅₀	5 pM Compound: 22, C0-NH2	Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]

In Vitro

DC0-NH2 (0-3 nM; 72 hours) is highly potent against Ramos, Namalwa, and HL60/s cells with IC₅₀ values in the 1 pM to 10 pM range, and has 100 pM range when tested on COLO 205 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Ramos, Namalwa, HL60/s, and COLO 205 Cancer Cells
Concentration:

0-3 nM
Incubation Time:

72 hours
Result:

Inhibited Namalwa and HL60/s cells with IC₅₀s of 7 and 30 pM, respectively.

Chemical Information

CAS. Nr. 615538-51-7
Appearance Solid
Molecular Weight 550.01
Formel C₃₁H₂₄ClN₅O₃
Color Light brown to brown
SMILES

O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (90.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8181 mL

9.0907 mL

18.1815 mL

5 mM

0.3636 mL

1.8181 mL

3.6363 mL

10 mM

0.1818 mL

0.9091 mL

1.8181 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8181 mL	9.0907 mL	18.1815 mL	45.4537 mL
	5 mM	0.3636 mL	1.8181 mL	3.6363 mL	9.0907 mL
	10 mM	0.1818 mL	0.9091 mL	1.8181 mL	4.5454 mL
	15 mM	0.1212 mL	0.6060 mL	1.2121 mL	3.0302 mL
	20 mM	0.0909 mL	0.4545 mL	0.9091 mL	2.2727 mL
	25 mM	0.0727 mL	0.3636 mL	0.7273 mL	1.8181 mL
	30 mM	0.0606 mL	0.3030 mL	0.6060 mL	1.5151 mL
	40 mM	0.0455 mL	0.2273 mL	0.4545 mL	1.1363 mL
	50 mM	0.0364 mL	0.1818 mL	0.3636 mL	0.9091 mL
	60 mM	0.0303 mL	0.1515 mL	0.3030 mL	0.7576 mL
	80 mM	0.0227 mL	0.1136 mL	0.2273 mL	0.5682 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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DC0-NH2

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DC0-NH2 Related Classifications

HY-129379 Related Classifications