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Art. -Nr.: HY-112900

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DC41SMe

DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC₅₀s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.

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CAS. Nr.: 1354787-71-5
Formel: C₃₈H₃₆ClN₅O₄S₂
Molecular Weight:726.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DC41SMe Chemical Structure

CAS. Nr.: 1354787-71-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Duocarmycins

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Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	220 pM Compound: 26, DC41SMe	Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
HL-60	IC₅₀	25 pM Compound: 26, DC41SMe	Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
NAMALVA	IC₅₀	21 pM Compound: 26, DC41SMe	Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
Ramos	IC₅₀	18 pM Compound: 26, DC41SMe	Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]

Chemical Information

CAS. Nr. 1354787-71-5
Molecular Weight 726.31
Formel C₃₈H₃₆ClN₅O₄S₂
SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCC(SSC)(C)C)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [Content Brief]

[2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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DC41SMe

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DC41SMe Related Classifications

HY-112900 Related Classifications