DNMT1-IN-5
DNMT1-IN-5 (Compound 55) is the inhibitor for DNMT that inhibits DNMT1 and DNMT3A with IC50 of 2.42 μM and 14.4 μM. DNMT1-IN-5 exhibits antiproliferative activity in a variety of cancer cell lines (IC50s for TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226 and HCT116 are 0.19-2.37 μM), arrests the cell cycle at G2/M phase, and induces apoptosis in TMD-8 and DOHH2 cells. DNMT1-IN-5 exhibits antitumor efficacy in TMD-8 xenograft mouse models.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2982511-19-1
- Formel: C24H32FN7
- Molecular Weight:437.56
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle DNA Methyltransferase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
DNMT1 2.42 μM (IC50) |
DNMT3A 14.4 μM (IC50) |
Chemical Information
-
CAS. Nr. 2982511-19-1
-
Molecular Weight 437.56
-
Formel C24H32FN7
-
SMILES
CN1CCC(NC2=C3C(N(C=C3)CCCN4CCCC4)=NC(C5=CC=NC(F)=C5)=N2)CC1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DNMT1-IN-5 Related Classifications
HY-172217 Related Classifications
Powered by Bioz