CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

Also Known as CNK; CNK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10256

About CNKSR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,177,491-26,189,884 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues.

Summary

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CNKSR1 Products (3)

mRNA Protein Name
NM_001297647.2 NP_001284576.1 connector enhancer of kinase suppressor of ras 1 isoform 2
NM_001297648.2 NP_001284577.1 connector enhancer of kinase suppressor of ras 1 isoform 3
NM_006314.3 NP_006305.2 connector enhancer of kinase suppressor of ras 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
14749388 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cell cortex IDA
IDA: Inferred from direct assay
15075335 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNKSR1 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (6 - 67)

CRIC_ras_sig

CRIC_ras_sig: Connector enhancer of kinase suppressor of ras (78 - 162)

PH

PH: PH domain (406 - 502)

  • 0
  • 200
  • 400
  • 600
  • 720 a.a.
Protein Preferred Names Protein Names

connector enhancer of kinase suppressor of ras 1

  • CNK homolog protein 1

CNKSR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CNKSR1 Q969H4 CYTH4 Homo sapiens Q8WWE8
Y2H Prey Pooling
25416956
Intra
CNKSR1 Q969H4 CYTH4 Homo sapiens Q8WWE8
Validated Y2H
25416956
Intra
CNKSR1 Q969H4 CYTH4 Homo sapiens Q8WWE8
Y2H Array
25416956
Intra
CNKSR1 Q969H4 CYTH4 Homo sapiens Q9UIA0
Y2H Array
31515488
Intra
CNKSR1 Q969H4 CYTH4 Homo sapiens Q9UIA0
Validated Y2H
32296183
Intra
CNKSR1 Q969H4 CYTH3 Homo sapiens O43739-2
Anti Tag CoIP
28514442
Intra
CNKSR1 Q969H4 TCAF1 Homo sapiens Q9Y4C2-2
Validated Y2H
32296183
Intra
CNKSR1 Q969H4 CYTH2 Homo sapiens Q99418
Validated Y2H
32296183
Intra
CNKSR1 Q969H4 CYTH2 Homo sapiens Q99418
Anti Tag CoIP
33961781
Intra
CNKSR1 Q969H4 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra
CNKSR1 Q969H4 CYTH3 Homo sapiens O43739
Anti Tag CoIP
33961781
Intra
CNKSR1 Q969H4 CYTH3 Homo sapiens O43739
Y2H Prey Pooling
25416956
Intra
CNKSR1 Q969H4 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
33961781
Intra
CNKSR1 Q969H4 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02888 CNKSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CNKSR1 VGNC VGNC:97254
Rattus norvegicus CNKSR1 RGD RGD:1311879
Mus musculus CNKSR1 MGD MGI:2670958
Canis familiaris CNKSR1 VGNC VGNC:39403
Macaca mulatta CNKSR1 VGNC VGNC:71222
Felis catus CNKSR1 VGNC VGNC:61017
Others CNKSR1 NCBI