CD93 - CD93 molecule Gene

Also Known as C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22918

About CD93

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,079,360-23,086,324 (from NCBI)

This gene has 1 transcript (splice variant), 266 orthologues and 8 paralogues. Broad expression in placenta (RPKM 64.0), lung (RPKM 47.5) and 21 other tissues.

Summary

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the Cytoskeleton and in the remodelling of the Cytoskeleton. [provided by RefSeq, Jul 2008]

CD93 Products (1)

mRNA Protein Name
NM_012072.4 NP_036204.2 complement component C1q receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables complement component C1q complex binding IDA
IDA: Inferred from direct assay
11781389 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15459234 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
28671670 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
28671670 GOA
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
11994479 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD93 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (44 - 153)

cEGF

cEGF: Complement Clr-like EGF-like (326 - 348)

EGF_CA

EGF_CA: Calcium-binding EGF domain (385 - 425)

EGF_CA

EGF_CA: Calcium-binding EGF domain (427 - 467)

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  • 652 a.a.
Protein Preferred Names Protein Names

complement component C1q receptor

  • C1q receptor 1

Recombinant CD93 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7691 CD93/C1qR1 Protein, Human (HEK293, His) Q9NPY3 (A24-K580) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78098 CD93/C1qR1 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NPY3 (T22-K580) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P990572 DCBY02 Inhibitor 98.71% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02278 CD93 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17287 Cd93 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23742 Cd93 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P992117 Lexucitug Inhibitor 98.04% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CD93 VGNC VGNC:80061
Macaca mulatta CD93 VGNC VGNC:70725
Rattus norvegicus CD93 RGD RGD:621251
Canis familiaris CD93 VGNC VGNC:58296
Bos taurus CD93 VGNC VGNC:52749
Mus musculus CD93 MGD MGI:106664
Others CD93 NCBI