DOCK9 - dedicator of cytokinesis 9 Gene

Also Known as ZIZ1; ZIZIMIN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23348

About DOCK9

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:98,793,429-99,088,619 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 10 paralogues. Ubiquitous expression in placenta (RPKM 21.7), thyroid (RPKM 20.1) and 23 other tissues.

Summary

Enables Cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

DOCK9 Products (14)

mRNA Protein Name
NM_001130048.2 NP_001123520.1 dedicator of cytokinesis protein 9 isoform b
NM_001130049.2 NP_001123521.1 dedicator of cytokinesis protein 9 isoform c
NM_001130050.2 NP_001123522.1 dedicator of cytokinesis protein 9 isoform d
NM_001318849.2 NP_001305778.1 dedicator of cytokinesis protein 9 isoform e
NM_001366676.2 NP_001353605.1 dedicator of cytokinesis protein 9 isoform 6
NM_001366677.2 NP_001353606.1 dedicator of cytokinesis protein 9 isoform 7
NM_001366678.2 NP_001353607.1 dedicator of cytokinesis protein 9 isoform 8
NM_001366679.2 NP_001353608.1 dedicator of cytokinesis protein 9 isoform 9
NM_001366680.2 NP_001353609.1 dedicator of cytokinesis protein 9 isoform 10
NM_001366681.2 NP_001353610.1 dedicator of cytokinesis protein 9 isoform 11
NM_001366682.2 NP_001353611.1 dedicator of cytokinesis protein 9 isoform 12
NM_001366683.2 NP_001353612.1 dedicator of cytokinesis protein 9 isoform 13
NM_001366684.2 NP_001353613.1 dedicator of cytokinesis protein 9 isoform 14
NM_015296.3 NP_056111.1 dedicator of cytokinesis protein 9 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
18729074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK9 Protein Structure

DUF3398

DUF3398: Domain of unknown function (DUF3398) (59 - 153)

PH

PH: PH domain (175 - 278)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (634 - 827)

DHR-2

DHR-2: Dock homology region 2 (1884 - 2060)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2068 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 9

  • cdc42 guanine nucleotide exchange factor zizimin-1

DOCK9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DOCK9 Q9BZ29 SMAD3 Homo sapiens P84022
TAP
18729074
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Irregular Astigmatism
Corneal Ectasia
Keratoconus

  • Kc

  • Conical Cornea

  • Noninflammatory Corneal Thining

  • Bulging Cornea

  • Cornea Conical

  • Acquired Conus Of Cornea
Gapo Syndrome

  • GAPOS

  • Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy

  • Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome

  • Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Corneal Dystrophy, Posterior Polymorphous, 1

  • Posterior Polymorphous Corneal Dystrophy

  • Ppcd

  • Maumenee Corneal Dystrophy

  • Posterior Polymorphous Corneal Dystrophy 1

  • PPCD1

  • Corneal Dystrophy, Hereditary Polymorphous Posterior

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant

  • Schlichting Dystrophy

  • Ched1

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

  • Ched1, Formerly

  • Hereditary Polymorphus Posterior Corneal Dystrophy

  • Posterior Polymorphous Dystrophy

  • Hereditary Polymorphous Posterior Corneal Dystrophy

  • Dystrophy, Corneal, Posterior Polymorphous

  • Dystrophy, Corneal, Posterior Polymorphous, Type 1

  • Polymorphous Corneal Dystrophy

  • Corneal Endothelial Dystrophy 2
Brittle Cornea Syndrome 1

  • Brittle Cornea Syndrome

  • Fragilitas Oculi With Joint Hyperextensibility

  • Dysgenesis Mesodermalis Corneae Et Sclerae

  • BCS1

  • Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

  • Ehlers-Danlos Syndrome, Type Vib, Formerly

  • Eds6b, Formerly

  • Type Vib Ehlers-Danlos Syndrome

  • Eds Vib

  • Ehlers-Danlos Syndrome Type 6b

  • Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

  • Eds6b Formerly

  • Ehlers-Danlos Syndrome Type Vib Formerly

  • Ehlers-Danlos Syndrome Type 6

  • Cornea, Brittle, Syndrome

  • Cornea, Brittle, Syndrome, Type 1

  • Ehlers-Danlos Syndrome 6b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-110100 CPYPP Inhibitor 99.80% Unkown
HY-RS03931 DOCK9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DOCK9 VGNC VGNC:61578
Rattus norvegicus DOCK9 RGD RGD:629617
Canis familiaris DOCK9 VGNC VGNC:40053
Bos taurus DOCK9 VGNC VGNC:28163
Mus musculus DOCK9 MGD MGI:106321
Macaca mulatta DOCK9 VGNC VGNC:71835
Others DOCK9 NCBI