Nedd8 - NEDD8 ubiquitin like modifier Gene

Also Known as CDK8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25490

Summary

Predicted to enable protein tag and ubiquitin protein Ligase binding activity. Involved in protein neddylation and response to organic cyclic compound. Located in nucleus. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]

Nedd8 Products (1)

mRNA Protein Name
NM_138878.2 NP_620233.1 NEDD8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21808025 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in protein neddylation IDA
IDA: Inferred from direct assay
17950367 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
14557245 RGD
Cellular Component GO Annotation Evidence Verweise Source
is active in postsynapse IDA
IDA: Inferred from direct assay
32726795 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD8

  • neddylin

  • neural precursor cell expressed, developmentally down-regulated 8

  • neural precursor cell expressed, developmentally down-regulated gene 8

  • ubiquitin-like protein Nedd8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-70062 Pevonedistat 99.98% Phase 3
HY-10484 Pevonedistat hydrochloride 99.19% Phase 3
HY-128586 TAS4464 99.21% Phase 1
HY-128586A TAS4464 hydrochloride 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-108702 ML-792 Inhibitor 99.76% Unkown
HY-101790A ZM223 hydrochloride Inhibitor 98.93% Unkown
HY-115537 NAE-IN-M22 Activator 99.94% Unkown
HY-101790 ZM223 Inhibitor / Unkown
HY-163105 Tubulin/NEDDylation-IN-1 Inhibitor 98.03% Unkown
HY-RS09181 NEDD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-70062R Pevonedistat (Standard) 99.51% Unkown
HY-159601 CSN5-IN-1 Inhibitor / Unkown
HY-181795 CSN5-IN-3 / Unkown
HY-177936 NAE-IN-3 Inhibitor / Unkown
HY-RS17081 Nedd8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23525 Nedd8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nedd8 NCBI NCBI:4738