NEDD8 - NEDD8 ubiquitin like modifier Gene

Homo sapiens

Also known as NEDD-8

Gene ID: 4738 | Gene type: protein coding

About NEDD8

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,216,857-24,232,367 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 217 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Apr 2022]

NEDD8 Products(1)

mRNA	Protein	Name
NM_006156.3	NP_006147.1	NEDD8

NEDD8 Protein Structure

ubiquitin

0
81 a.a.

Protein Preferred Names

Protein Names

NEDD8

neddylin

Recombinant NEDD8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70843	NEDD8 Protein, Human	Q15843 (M1-G76)	≥95%

Related Diseases

Diseases

Alias

Malignant Astrocytoma

Astrocytic Tumor	Astrocytoma Of Brain
Astrocytoma Of Cerebrum	Astroglioma
Cerebral Astrocytoma	Astrocytoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-70062	Pevonedistat	Inhibitor	99.98%	Phase 3
HY-10484	Pevonedistat hydrochloride	Inhibitor	99.26%	Phase 3
HY-128586	TAS4464	Inhibitor	99.52%	Phase 2
HY-128586A	TAS4464 hydrochloride	Inhibitor	98.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108702	ML-792	Inhibitor	99.90%	Unkown
HY-101790A	ZM223 hydrochloride	Inhibitor	99.21%	Unkown
HY-101790	ZM223	Inhibitor	/	Unkown
HY-163105	Tubulin/NEDDylation-IN-1	Inhibitor	98.03%	Unkown
HY-115537	NAE-IN-M22	Activator	99.67%	Unkown
HY-RS09181	NEDD8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NEDD8	VGNC	VGNC:80899
Mus musculus	NEDD8	MGD	MGI:97301
Canis familiaris	NEDD8	VGNC	VGNC:56061
Rattus norvegicus	NEDD8	RGD	RGD:3158

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