STON2 - stonin 2 Gene

Also Known as STN2; STNB; STNB2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85439

About STON2

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:81,260,652-81,436,465 (from NCBI)

This gene has 9 transcripts (splice variants), 165 orthologues and 7 paralogues. Broad expression in brain (RPKM 5.7), spleen (RPKM 3.8) and 19 other tissues.

Summary

This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

STON2 Products (4)

mRNA Protein Name
NM_001256430.3 NP_001243359.1 stonin-2 isoform 2
NM_001366849.2 NP_001353778.1 stonin-2 isoform 3
NM_001366850.2 NP_001353779.1 stonin-2 isoform 4
NM_001394390.1 NP_001381319.1 stonin-2 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11454741 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in synaptic vesicle endocytosis IGI
IGI: Inferred from genetic interaction
21102408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STON2 Protein Structure

Stonin2_N

Stonin2_N: Stonin 2 (1 - 340)

Adap_comp_sub

Adap_comp_sub: Adaptor complexes medium subunit family (559 - 872)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 905 a.a.
Protein Preferred Names Protein Names

stonin-2

  • stoned B homolog 2

STON2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
STON2 Q8WXE9 EPS15 Homo sapiens P42566
NMR
18200045
Intra
STON2 Q8WXE9 EPS15 Homo sapiens P42566
ITC
18200045
Intra
STON2 Q8WXE9 EPS15 Homo sapiens P42566
Anti Bait CoIP
18200045
Cross
STON2 Q8WXE9 Syt1 Rattus norvegicus P21707
Pull Down
11454741
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Keratoconus

  • Kc

  • Conical Cornea

  • Noninflammatory Corneal Thining

  • Bulging Cornea

  • Cornea Conical

  • Acquired Conus Of Cornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13953 STON2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STON2 MGD MGI:1918272
Rattus norvegicus STON2 RGD RGD:1311502
Macaca mulatta STON2 VGNC VGNC:78249
Bos taurus STON2 VGNC VGNC:35413
Felis catus STON2 VGNC VGNC:65796
Canis familiaris STON2 VGNC VGNC:46933
Others STON2 NCBI