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ANXA4 - annexin A4 Gene

Also Known as ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 307

About ANXA4

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,643,808-69,827,112 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in gall bladder (RPKM 187.6), duodenum (RPKM 64.1) and 17 other tissues.

Summary

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with Other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits Phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

ANXA4 Products (5)

mRNA	Protein	Name
NM_001153.5	NP_001144.1	annexin A4 isoform a
NM_001320698.2	NP_001307627.1	annexin A4 isoform a
NM_001320700.2	NP_001307629.1	annexin A4 isoform b
NM_001320702.2	NP_001307631.1	annexin A4 isoform c
NM_001365496.2	NP_001352425.1	annexin A4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	20237821	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	20237821	GOA
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	2138016	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	15226301	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16687573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	20237821	GOA
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22056994	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20237821	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	22056994	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20237821	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	16687573	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16687573	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16687573	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16687573	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	16687573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA4 Protein Structure

Annexin

0
100
200
300
321 a.a.

Protein Preferred Names	Protein Names
annexin A4	35-beta calcimedin

ANXA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ANXA4	P09525	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	ANXA4	P09525	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	ANXA4	P09525	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	ANXA4	P09525	PADI4	Homo sapiens	Q9UM07	Y2H Array	32296183
Intra	ANXA4	P09525	PADI4	Homo sapiens	Q9UM07	Y2H Prey Pooling	32296183
Intra	ANXA4	P09525	PADI4	Homo sapiens	Q9UM07	Validated Y2H	32296183
Intra	ANXA4	P09525	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	ANXA4	P09525	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Intra	ANXA4	P09525	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	ANXA4	P09525	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	ANXA4	P09525	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	ANXA4	P09525	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	ANXA4	P09525	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	ANXA4	P09525	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	ANXA4	P09525	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	ANXA4	P09525	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	ANXA4	P09525	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	ANXA4	P09525	CRYAB	Homo sapiens	P02511	Y2H Array	32814053
Intra	ANXA4	P09525	CRYAB	Homo sapiens	P02511	Y2H Pooling	32814053
Intra	ANXA4	P09525	CRYAB	Homo sapiens	P02511	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

ANXA4 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82176	Annexin-4/ANXA4 Antibody (YA1921)	WB, ICC/IF, FC	Human
HY-P82969	Annexin-4/ANXA4 Antibody (YA2714)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P82969A	Annexin-4/ANXA4 Antibody (YA2714)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS25291	Anxa4 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANXA4	VGNC	VGNC:37941
Macaca mulatta	ANXA4	VGNC	VGNC:69949
Mus musculus	ANXA4	MGD	MGI:88030
Bos taurus	ANXA4	VGNC	VGNC:25966
Felis catus	ANXA4	VGNC	VGNC:79989
Rattus norvegicus	ANXA4	RGD	RGD:621171
Others	ANXA4	NCBI