MXI1 - MAX interactor 1, dimerization protein Gene

Also Known as MXI; MAD2; MXD2; bHLHc11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4601

About MXI1

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,207,605-110,287,365 (from NCBI)

This gene has 38 transcripts (splice variants), 258 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 23.6), brain (RPKM 22.2) and 25 other tissues.

Summary

Expression of the c-Myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

MXI1 Products (3)

mRNA Protein Name
NM_001008541.1 NP_001008541.1 max-interacting protein 1 isoform c
NM_005962.5 NP_005953.4 max-interacting protein 1 isoform a
NM_130439.3 NP_569157.2 max-interacting protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11875718 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8425219 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9184233 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11875718 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
8425219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MXI1 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (69 - 120)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

max-interacting protein 1

  • MAX dimerization protein 2

MXI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
MXI1 P50539 MAX Homo sapiens P61244-2
Y2H Prey Pooling
25416956
Intra
MXI1 P50539 ENTPD5 Homo sapiens O75356
Y2H Prey Pooling
25416956
Intra
MXI1 P50539 MAX Homo sapiens P61244
Y2H
9184233
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Neurofibrosarcoma

  • Neurosarcoma

  • Malignant Peripheral Nerve Sheath Tumor
Prostatic Adenoma

  • Prostatic Hyperplasia

  • Adenoma - Prostate

  • Adenoma Of Prostate

  • Benign Adenoma Of Prostate

  • Prostate Adenoma

  • Benign Prostatic Hyperplasia
Shigellosis

  • Dysentery, Bacillary

  • Bacillary Dysentery

  • Shigella Boydii Infectious Disease

  • Shigella Flexneri Infectious Disease

  • Shigella Gastroenteritis

  • Shigella Sonnei Infectious Disease

  • Shigella Infections
Small Cell Carcinoma

  • Small Cell Carcinoma, Intermediate Cell

  • Intermediate Cell Small Cell Carcinoma

  • Small Cell Carcinoma - Intermediate Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Glanders

  • Farcy Pipes

  • Infection Due To Pseudomonas Mallei

  • Burkholderia Mallei

  • Burkholderia Mallei Infection

  • Equina

  • Equine Glanders

  • Farcy

  • Farcy Buds

  • Farcy Cords

  • Infection Due To Actinobacillus Mallei

  • Infection Due To Malleomyces Mallei

  • Maliasmus

  • Malleus

  • Farce

  • Actinobacillosis

  • Actinobacillus Infection
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08864 MXI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21382 Mxi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27901 Mxi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MXI1 VGNC VGNC:31773
Canis familiaris MXI1 VGNC VGNC:43515
Felis catus MXI1 VGNC VGNC:68366
Mus musculus MXI1 MGD MGI:97245
Macaca mulatta MXI1 VGNC VGNC:75087
Rattus norvegicus MXI1 RGD RGD:3128
Others MXI1 NCBI