PGAM1 - phosphoglycerate mutase 1 Gene

Also Known as PGAMA; PGAM-B; HEL-S-35

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5223

About PGAM1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,426,191-97,433,444 (from NCBI)

This gene has 3 transcripts (splice variants), 234 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 137.6), brain (RPKM 137.2) and 25 other tissues.

Summary

The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

PGAM1 Products (2)

mRNA Protein Name
NM_001317079.2 NP_001304008.1 phosphoglycerate mutase 1 isoform 2
NM_002629.4 NP_002620.1 phosphoglycerate mutase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IDA
IDA: Inferred from direct assay
23653202 GOA
enables bisphosphoglycerate mutase activity IDA
IDA: Inferred from direct assay
23653202 GOA
enables phosphoglycerate mutase activity EXP
EXP: Inferred from Experiment
4827367 GOA
enables phosphoglycerate mutase activity IDA
IDA: Inferred from direct assay
22590500 GOA
enables phosphoglycerate mutase activity IMP
IMP: Inferred from mutant phenotype
12189148 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16049941 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12189148 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
12189148 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22590500 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12189148 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGAM1 Protein Structure

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (5 - 191)

  • 0
  • 100
  • 200
  • 254 a.a.
Protein Preferred Names Protein Names

phosphoglycerate mutase 1

  • BPG-dependent PGAM 1

PGAM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PGAM1 P18669 UNC5CL Homo sapiens Q8IV45
Validated Y2H
32296183
Intra
PGAM1 P18669 PCNA Homo sapiens P12004
Far-WB
20849852
Cross: Cross-species interaction Intra: Intraspecies interaction

PGAM1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82411 PGAM1 Antibody (YA2156) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Menkes Disease

  • Copper Transport Disease

  • Menkes Syndrome

  • MNK

  • Kinky Hair Disease

  • Steely Hair Disease

  • Menkes Kinky-Hair Syndrome

  • Mk

  • Steely Hair Syndrome

  • Menkea Syndrome

  • Md

  • Menkes Kinky Hair Syndrome

  • Hypocupremia, Congenital

  • Kinky Hair Syndrome

  • X-Linked Copper Deficiency

  • Menkes Kinky Hair Disease
Myoglobinuria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-148510 HKB99 99.65% Unkown
HY-101143 PGMI-004A Inhibitor 98.87% Unkown
HY-128681 PGAM1-IN-1 Inhibitor 99.83% Unkown
HY-128682 PGAM1-IN-2 Inhibitor 98.02% Unkown
HY-RS10374 PGAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17711 Pgam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24176 Pgam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PGAM1 RGD RGD:3312
Bos taurus PGAM1 VGNC VGNC:55961
Mus musculus PGAM1 MGD MGI:97552
Canis familiaris PGAM1 VGNC VGNC:56113
Others PGAM1 NCBI