UNC5CL - unc-5 family C-terminal like Gene

Also Known as ZUD; MUXA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222643

Summary

Enables peptidase activity. Acts upstream of or within positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Jun 2026]
Biased expression in duodenum (RPKM 20.3), small intestine (RPKM 16.3) and 6 other tissues.

UNC5CL Products (1)

mRNA Protein Name
NM_173561.3 NP_775832.2 UNC5C-like protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
22158417 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
22158417 GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
22158417 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
22158417 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC5CL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UNC5CL Q8IV45 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
UNC5CL Q8IV45 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
UNC5CL Q8IV45 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
UNC5CL Q8IV45 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
UNC5CL Q8IV45 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
UNC5CL Q8IV45 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
UNC5CL Q8IV45 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
UNC5CL Q8IV45 TOX2 Homo sapiens Q96NM4-3
Validated Y2H
32296183
Intra
UNC5CL Q8IV45 TOX2 Homo sapiens Q96NM4-3
Y2H Prey Pooling
32296183
Intra
UNC5CL Q8IV45 TOX2 Homo sapiens Q96NM4-3
Y2H Array
32296183
Intra
UNC5CL Q8IV45 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
UNC5CL Q8IV45 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
UNC5CL Q8IV45 PGAM1 Homo sapiens P18669
Y2H Array
32296183
Intra
UNC5CL Q8IV45 PGAM1 Homo sapiens P18669
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16404 UNC5CL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21217 Unc5cl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27733 Unc5cl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown