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NR4A3 - nuclear receptor subfamily 4 group A member 3 Gene

Also Known as CHN; CSMF; NOR1; MINOR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8013

About NR4A3

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,821,885-99,866,891 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 69 phenotypes. Biased expression in adrenal (RPKM 28.0), urinary bladder (RPKM 16.9) and 13 other tissues.

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and Other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

NR4A3 Products (3)

mRNA	Protein	Name
NM_006981.4	NP_008912.2	nuclear receptor subfamily 4 group A member 3 isoform a
NM_173199.4	NP_775291.1	nuclear receptor subfamily 4 group A member 3 isoform c
NM_173200.3	NP_775292.1	nuclear receptor subfamily 4 group A member 3 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20558821	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12543801	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25852083	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	23554459	GOA
involved in positive regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	24022864	GOA
involved in positive regulation of monocyte aggregation	IMP IMP: Inferred from mutant phenotype	20558821	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20558821	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	23554459	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	23554459	GOA
involved in regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	25852083	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR4A3 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
626 a.a.

Protein Preferred Names	Protein Names
nuclear receptor subfamily 4 group A member 3	chondrosarcoma, extraskeletal myxoid, fused to EWS

NR4A3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NR4A3	Q92570	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	NR4A3	Q92570	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	NR4A3	Q92570	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	NR4A3	Q92570	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	NR4A3	Q92570	PCSK5	Homo sapiens	Q92824-2	Validated Y2H	32296183
Intra	NR4A3	Q92570	KRTAP4-4	Homo sapiens	Q9BYR3	Validated Y2H	32296183
Intra	NR4A3	Q92570	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	NR4A3	Q92570	SMOC1	Homo sapiens	Q9H4F8-2	Validated Y2H	32296183
Intra	NR4A3	Q92570	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	NR4A3	Q92570	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	NR4A3	Q92570	NECTIN2	Homo sapiens	Q92692-2	Validated Y2H	32296183
Intra	NR4A3	Q92570	CHRD	Homo sapiens	Q9H2X0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Myxoid Chondrosarcoma
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Vulvar Sarcoma	Sarcoma Of Vulva Vulva Sarcoma
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Parachordoma
Bone Chondrosarcoma
Acinar Cell Carcinoma	Acinic Cell Carcinoma Acinic Cell Tumor Carcinoma Acinar Cell Carcinoma, Acinar Cell Acinar Cell Tumor
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Bone Sarcoma
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09552	NR4A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18292	Nr4a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24770	Nr4a3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR4A3	VGNC	VGNC:32247
Macaca mulatta	NR4A3	VGNC	VGNC:75519
Felis catus	NR4A3	VGNC	VGNC:68556
Rattus norvegicus	NR4A3	RGD	RGD:61882
Mus musculus	NR4A3	MGD	MGI:1352457
Others	NR4A3	NCBI