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Art. -Nr.: HY-15007

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L 366509

L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists.

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CAS. Nr.: 138382-23-7
Formel: C₂₅H₃₃NO₅S
Molecular Weight:459.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

L 366509 Chemical Structure

CAS. Nr.: 138382-23-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Beschreibung

Chemical Information

CAS. Nr. 138382-23-7
Molecular Weight 459.60
Formel C₂₅H₃₃NO₅S
SMILES

O=S(N(CC1)CCC21C3=CC=CC=C3C=C2)(C[C@]4(C5(C)C)CC[C@@H]5C[C@@]4(CC(O)=O)O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. 1- (( (7,7-Dimet hyl-2( S)-(2( S)-amino-4- (met hylsulfonyl) butyramido) bicyclo[2.2.1]- heptan-l( S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): An Orally Bioavailable, Non-Peptide Oxytocin Antagonist with Potential Utility for Managing Preterm Labor

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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L 366509

Oxytocin acetate

Cligosiban

Retosiban

LIT-001

SHR1653

WAY-267464 hydrochloride

L-372662

OT-R antagonist 1

OT-R antagonist 2

(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin

Demoxytocin

Cligosiban (Standard)

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

L 366509

Oxytocin acetate

Cligosiban

Retosiban

LIT-001

SHR1653

WAY-267464 hydrochloride

L-372662

OT-R antagonist 1

OT-R antagonist 2

(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin

Demoxytocin

Cligosiban (Standard)

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

L 366509 Related Classifications

HY-15007 Related Classifications