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Art. -Nr.: HY-186116

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LSD1-IN-49

LSD1-IN-49 is a Lysine-specific demethylase 1 (LSD1/KDM1A) inhibitor with a human IC₅₀ of 29 nM. LSD1-IN-49 irreversibly inhibits LSD1 enzyme activity by forming an adduct with the flavin adenine dinucleotide (FAD) cofactor of LSD1. LSD1-IN-49 can be used as a lead compound for the development of LSD1-targeted PET imaging agents for the brain.

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CAS. Nr.: 1422533-70-7
Formel: C₂₆H₂₆N₂O
Molecular Weight:382.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSD1-IN-49 Chemical Structure

CAS. Nr.: 1422533-70-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

LSD1

29 nM (IC₅₀)

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen :

In Vitro

LSD1-IN-49 (compound (±)1) (15 min) potently inhibits human recombinant LSD1/CoREST enzyme with an IC₅₀ of 29 nM^[1].
LSD1-IN-49 (1 μM; 1 h) has an MDR1 efflux ratio of 0.8 when tested in human MDR1-expressing LLC-PK1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1422533-70-7
Molecular Weight 382.50
Formel C₂₆H₂₆N₂O
SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC(C=C3)=CC=C3[C@H](C4)[C@@H]4NCC5CC5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hattori Y, et al. Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain. J Med Chem. 2021;64(7):3780-3793. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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LSD1-IN-49

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen

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Chemical Information

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LSD1-IN-49 Related Classifications

HY-186116 Related Classifications