ME67
ME67 (EM-B enol ether) is a motilin receptor (Motilin Receptor) agonist with pIC50 values of 8.38 and 6.49 for rabbit and human motilin receptors, respectively. ME67 activates the G protein-coupled Motilin Receptor, inducing calcium mobilization, calcium flux, receptor internalization, and gastrointestinal motility. ME67 can be used in research on gastrointestinal motility disorders.
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- CAS. Nr.: 33275-72-8
- Formel: C37H65NO11
- Molecular Weight:699.91
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
ME67 induces calcium ion release in CHO-K1 cells expressing the human motilin receptor, with a pEC50 of 8.12[1].
ME67 contracts rabbit duodenal segments with a pEC50 of 7.11 and binds to rabbit antral motilin receptors with a pIC50 of 8.38[1].
ME67 activates Ca2+ flux in CHO-K1 cells expressing human MTLR and apoaequorin, with a pEC50 of 8.12, and desensitizes the subsequent motilin response with a pDC50 of 6.03[2].
ME67 (10−12-10−4 M; 60 min) binds to the human motilin receptor in CHO-MTLR membranes with a pIC50 of 6.49[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 33275-72-8
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Molecular Weight 699.91
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Formel C37H65NO11
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SMILES
C[C@]1(OC([C@@H]([C@H]([C@H]([C@H](OC([C@@H]([C@H]([C@@H]2C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)=O)CC)C)O)C)=C(C1)C)[C@@H]2O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O
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Synonyms
EM-B enol ether
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Thielemans L, et al. The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochemical and biophysical research communications. 2002 May 17;293(4):1223-7. [Content Brief]
[2]. Thielemans L, et al. Desensitization of the human motilin receptor by motilides. The Journal of pharmacology and experimental therapeutics. 2005 Jun;313(3):1397-405. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ME67 Related Classifications
HY-187989 Related Classifications
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