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Art. -Nr.: HY-182426

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NCX-278

NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM K_i for hCA II, 410 nM K_i for hCA I, 181 nM K_i for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC₅₀ of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma.

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CAS. Nr.: 1202697-61-7
Formel: C₁₄H₂₁N₃O₉S₃
Molecular Weight:471.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NCX-278 Chemical Structure

CAS. Nr.: 1202697-61-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

hCA II

13 nM (Ki)

hCA I

410 nM (Ki)

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen :

In Vitro

NCX-278 potently inhibits recombinant human hCA II with a K_i of 13 nM, and shows 13.9-fold selectivity for hCA II over hCA IV, while inhibiting hCA I with a K_i of 410 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max
Rat^[1]	55 mM	o.a.	120 min

In Vivo

NCX-278 (55 mM; o.a.; single dose) produces a statistically significant maximal intraocular pressure reduction of -3.7 mmHg in normotensive New Zealand white rabbits, with peak effect at 120 minutes post-dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

New Zealand white rabbits^[1]
Dosage:

55 mM
Administration:

o.a.; single dose
Result:

Reduced intraocular pressure to a maximal effect of -3.7 mmHg.
Reached peak effect at 120 minutes post-dosing.
Returned to basal intraocular pressure levels at 360 minutes post-dosing.

Chemical Information

CAS. Nr. 1202697-61-7
Molecular Weight 471.53
Formel C₁₄H₂₁N₃O₉S₃
SMILES

O=C(OCCCO[N+]([O-])=O)N([C@@H]1C2=C(S(=O)([C@H](C1)C)=O)SC(S(N)(=O)=O)=C2)CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Steele RM, et al. Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6565-70. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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NCX-278

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

NCX-278 Related Classifications

HY-182426 Related Classifications